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dc.contributor.author
Wang, Yuemin
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dc.contributor.author
Quan, Fei
dc.contributor.author
Cao, Qiuhua
dc.contributor.author
Lin, Yanting
dc.contributor.author
Yue, Chongxiu
dc.contributor.author
Bi, Ran
dc.contributor.author
Cui, Xinmeng
dc.contributor.author
Yang, Hongbao
dc.contributor.author
Yang, Yong
dc.contributor.author
Birnbaumer, Lutz
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dc.contributor.author
Li, Xianjing
dc.contributor.author
Gao, Xinghua
dc.date.available
2022-09-23T15:11:12Z
dc.date.issued
2021-02
dc.identifier.citation
Wang, Yuemin; Quan, Fei; Cao, Qiuhua; Lin, Yanting; Yue, Chongxiu; et al.; Quercetin alleviates acute kidney injury by inhibiting ferroptosis; Elsevier; Journal of Advanced Research; 28; 2-2021; 231-243
dc.identifier.issn
2090-1232
dc.identifier.uri
http://hdl.handle.net/11336/170218
dc.description.abstract
Introduction: Ferroptosis is an iron-dependent regulated necrosis and has been proven to contribute to the progress of acute kidney injury (AKI). Quercetin (QCT), a natural flavonoid which is commonly found in numerous fruits and vegetables, has extensive pharmacological effects, such as anti-oxidant, anti-inflammatory and anti-senescence effects. Objectives: This study aims to explain whether ferroptosis is a therapeutic strategy to AKI, and to explore the effect of QCT on AKI ferroptosis. Methods: NRK-52E cells and HK-2 cells were used for in vitro ferroptosis studies. Morphology of cells was detected by transmission electron microscopy. Lipid ROS was assayed using flow cytometry. In vivo, AKI was induced by ischemia–reperfusion (I/R) or folic acid (FA). To explore the molecular mechanisms, RNA-sequence analysis was performed. Transwell was used to detect macrophage migration. Results: We discovered that quercetin (QCT), a natural flavonoid, inhibited ferroptosis in renal proximal tubular epithelial cells. QCT blocked the typical morphologic changes of ferroptotic cells by reducing the levels of malondialdehyde (MDA) and lipid ROS and increasing the levels of glutathione (GSH). Moreover, QCT ameliorated AKI induced by I/R or FA. RNA-sequence analysis highlighted activation transcription factor 3 (ATF3), as it was the dominant one among all the 299 down-regulated genes by QCT. Knockdown of ATF3 could significantly increase the levels of SLC7A11, GPX4 and increased the cell viability. In addition, ferroptotic cells were found to be extremely pro-inflammatory by recruiting macrophages through CCL2, while QCT inhibited the chemotaxis of macrophages induced by ferroptosis in AKI. Conclusions: Collectively, these results identify QCT as a ferroptosis inhibitor and provide new therapeutic strategies for diseases related to ferroptosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ACTIVATION TRANSCRIPTION FACTOR 3
dc.subject
ACUTE KIDNEY INJURY
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FERROPTOSIS
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MACROPHAGES
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QUERCETIN
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Quercetin alleviates acute kidney injury by inhibiting ferroptosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-09T17:22:22Z
dc.journal.volume
28
dc.journal.pagination
231-243
dc.journal.pais
Egipto
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dc.description.fil
Fil: Wang, Yuemin. China Pharmaceutical University; China
dc.description.fil
Fil: Quan, Fei. China Pharmaceutical University; China
dc.description.fil
Fil: Cao, Qiuhua. China Pharmaceutical University; China
dc.description.fil
Fil: Lin, Yanting. China Pharmaceutical University; China
dc.description.fil
Fil: Yue, Chongxiu. China Pharmaceutical University; China
dc.description.fil
Fil: Bi, Ran. China Pharmaceutical University; China
dc.description.fil
Fil: Cui, Xinmeng. China Pharmaceutical University; China
dc.description.fil
Fil: Yang, Hongbao. China Pharmaceutical University; China
dc.description.fil
Fil: Yang, Yong. China Pharmaceutical University; China. Xuzhou Medical University; China
dc.description.fil
Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Li, Xianjing. China Pharmaceutical University; China
dc.description.fil
Fil: Gao, Xinghua. China Pharmaceutical University; China
dc.journal.title
Journal of Advanced Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jare.2020.07.007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2090123220301661?via%3Dihub
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