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dc.contributor.author
He, DongXu
dc.contributor.author
Mao, AiQin
dc.contributor.author
Li, YouRan
dc.contributor.author
Tam, SiuCheung
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Zheng, YongTang
dc.contributor.author
Yao, XiaoQiang
dc.contributor.author
Birnbaumer, Lutz
dc.contributor.author
Ambudkar, Indu S.
dc.contributor.author
Ma, Xin
dc.date.available
2022-09-23T15:09:21Z
dc.date.issued
2021-03
dc.identifier.citation
He, DongXu; Mao, AiQin; Li, YouRan; Tam, SiuCheung; Zheng, YongTang; et al.; TRPC1 participates in the HSV-1 infection process by facilitating viral entry; Science Advances is the American Association for the Advancement of Science; Science Advances; 6; 12; 3-2021; 1-12
dc.identifier.issn
2375-2548
dc.identifier.uri
http://hdl.handle.net/11336/170216
dc.description.abstract
Mammalian transient receptor potential (TRP) channels are major components of Ca2+ signaling pathways and control a diversity of physiological functions. Here, we report a specific role for TRPC1 in the entry of herpes simplex virus type 1 (HSV-1) into cells. HSV-1-induced Ca2+ release and entry were dependent on Orai1, STIM1, and TRPC1. Inhibition of Ca2+ entry or knockdown of these proteins attenuated viral entry and infection. HSV-1 glycoprotein D interacted with the third ectodomain of TRPC1, and this interaction facilitated viral entry. Knockout of TRPC1 attenuated HSV-1-induced ocular abnormality and morbidity in vivo in TRPC1−/− mice. There was a strong correlation between HSV-1 infection and plasma membrane localization of TRPC1 in epithelial cells within oral lesions in buccal biopsies from HSV-1-infected patients. Together, our findings demonstrate a critical role for TRPC1 in HSV-1 infection and suggest the channel as a potential target for anti-HSV therapy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Science Advances is the American Association for the Advancement of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HSV-1-infected patients
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
TRPC1 participates in the HSV-1 infection process by facilitating viral entry
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-09T17:22:17Z
dc.journal.volume
6
dc.journal.number
12
dc.journal.pagination
1-12
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: He, DongXu. Jiangnan University; China
dc.description.fil
Fil: Mao, AiQin. Jiangnan University; China
dc.description.fil
Fil: Li, YouRan. Jiangnan University; China
dc.description.fil
Fil: Tam, SiuCheung. Chinese University Of Hong Kong; Hong Kong
dc.description.fil
Fil: Zheng, YongTang. Kunming Institute Of Zoology Chinese Academy Of Sciences; China
dc.description.fil
Fil: Yao, XiaoQiang. Chinese University Of Hong Kong; Hong Kong
dc.description.fil
Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Ambudkar, Indu S.. National Institute Of Dental And Craniofacial Research ; Estados Unidos
dc.description.fil
Fil: Ma, Xin. Jiangnan University; China
dc.journal.title
Science Advances
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1126/sciadv.aaz3367
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/epdf/10.1126/sciadv.aaz3367
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