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dc.contributor.author
Caraballo, Roberto Horacio
dc.contributor.author
Pociecha, Juan
dc.contributor.author
Reyes, Gabriela
dc.contributor.author
Espeche, Alberto Antonio
dc.contributor.author
Galichio, Santiago
dc.contributor.author
Fasulo, Lorena
dc.contributor.author
Semprino, Marcos
dc.date.available
2022-09-23T14:49:26Z
dc.date.issued
2020-07
dc.identifier.citation
Caraballo, Roberto Horacio; Pociecha, Juan; Reyes, Gabriela; Espeche, Alberto Antonio; Galichio, Santiago; et al.; Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox–Gastaut syndrome: A study of 34 patients; Academic Press Inc Elsevier Science; Epilepsy & Behavior (print); 108; 107074; 7-2020; 1-6
dc.identifier.issn
1525-5050
dc.identifier.uri
http://hdl.handle.net/11336/170200
dc.description.abstract
Objective: Here, we present a multicenter series of patients with developmental and epileptic encephalopathies (DEE) and related electroclinical patterns (REP) other than Lennox–Gastaut syndrome (LGS) who were treated with rufinamide as add-on therapy. Methods: Medical records of 34 patients with DEE and REP other than LGS treated with add-on rufinamide seen at four pediatric neurology centers in Argentina between May 2014 and March 2019 were retrospectively analyzed. Results: We evaluated 34 patients (18 males, 16 females), aged between 2 and 15 years with a mean and median age of 6 and 8 years, respectively. The children had different types of childhood-onset refractory DEE and REP other than LGS and were treated with rufinamide for a mean period of 20 months (range, 12–60 months). Twenty-two of 34 patients (64.5%) who received rufinamide as add-on therapy had a greater than 50% decrease in seizures, and two patients (5.8%) became seizure-free. Four patients (11.7%) had a 25–50% seizure reduction, while seizure frequency remained unchanged in four others (11.7%) and increased in two patients (5.8%). The final mean dosage of rufinamide was 31.5 ± 15.5 mg/kg per day (range, 19–75.4 mg/kg) if combined with valproic acid and of 35.4 ± 11.5 mg/kg per day (range, 8–60.5 mg/kg) without valproic acid. Adverse effects were recorded in nine patients (26.4%). A seizure increase was reported in two of 24 patients (7.3%). Conclusion: Rufinamide may be used as a treatment option in DEE and REP other than LGS.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
EPILEPTIC ENCEPHALOPATHIES
dc.subject
FOCAL AND GENERALIZED
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REFRACTORY
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RUFINAMIDE
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SEIZURES
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Neurología Clínica
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox–Gastaut syndrome: A study of 34 patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-22T15:00:38Z
dc.journal.volume
108
dc.journal.number
107074
dc.journal.pagination
1-6
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Caraballo, Roberto Horacio. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Pociecha, Juan. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Reyes, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Espeche, Alberto Antonio. Hospital Materno Infantil de Salta; Argentina
dc.description.fil
Fil: Galichio, Santiago. Hospital de Niños Víctor J Vilela; Argentina
dc.description.fil
Fil: Fasulo, Lorena. Clínica San Lucas; Argentina
dc.description.fil
Fil: Semprino, Marcos. Clínica San Lucas; Argentina
dc.journal.title
Epilepsy & Behavior (print)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.yebeh.2020.107074
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1525505020302535
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