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dc.contributor.author
Badano, Maria Noel
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Monzani, María Cecili
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Aloisi Zavala, Natalia Andrea
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Gualtieri, Ariel Félix
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Corti, Marcelo
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Parodi, María Cecilia
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Pinto, Tezanos
dc.contributor.author
Primiani, Laura
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Bracco, M. M. E. D.
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Chuit, Roberto
dc.contributor.author
Baré, Patricia
dc.date.available
2022-09-23T10:36:48Z
dc.date.issued
2020-07
dc.identifier.citation
Badano, Maria Noel; Monzani, María Cecili; Aloisi Zavala, Natalia Andrea; Gualtieri, Ariel Félix; Corti, Marcelo; et al.; Controlled HIV-HCV Viremia and Immune-Reconstitution are Associated with Slow Progression of Liver Disease in Co-infected Hemophilic Patients After 30 Years of Follow-Up; Japanese Journal of Gastroenterology and Hepatology; Japanese Journal of Gastroenterology and Hepatology; 7-2020; 1-7
dc.identifier.issn
2435-1210
dc.identifier.uri
http://hdl.handle.net/11336/170117
dc.description.abstract
Introduction and aim: Controversial results have been reported about the progressionof liver disease in HIV-HCV coinfected populations. The purpose of this study is to assesslong-term liver disease progression in a group of coinfected patients with hemophilia.1.2. Materials and Methods: From 1995 to 2015, liver disease was assessed through enzymelevels, platelet counts, Hepatitis C and HIV viral loads (VL), and CD4+T cell counts. Evolution of the APRI liver index was used to estimate hepatic disease (APRI > 1.0 indicatingsevere fibrosis).1.3. Results: 2005-2015 proportional liver-related mortality was below 17% while AIDSand other causes including hemorrhagic events reached 42% each. APRI index >1.0 wasfound in 3 of 32 (9%) patients alive, showing significant liver disease after more than 30years of infection. Analyzing the evolution of liver disease markers, liver enzymes increasedsignificantly only in those patients with detectable HIV and /or HCV VL (for AST and ALT,p<0.0001; for GGT, p=0.001). HIV suppression and reconstitution of CD4+T cell countswere required to achieve HCV eradication. Through multivariate logistic regression, pre ART(pre-antiretroviral therapy) HIV VL was associated with the development of liver fibrosis(OR=4.755; IC95: 1.057 21.387) and with altered liver enzyme values (OR=4.091; IC95:1.293 ? 12.947). No persistent increase in enzyme levels or APRI index was observed in thegroup controlling HIV and HCV replication and adequate immune recovery.1.4. Conclusions: The suppression of both viruses, HIV and HCV, together with adequateimmune recovery is associated with minimal or slow progression of liver disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Japanese Journal of Gastroenterology and Hepatology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HIV-HCV COINFECTION
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LIVER DISEASE PROGRESSION
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HEMOPHILIA
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Virología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Controlled HIV-HCV Viremia and Immune-Reconstitution are Associated with Slow Progression of Liver Disease in Co-infected Hemophilic Patients After 30 Years of Follow-Up
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T19:13:41Z
dc.journal.pagination
1-7
dc.journal.pais
Japón
dc.description.fil
Fil: Badano, Maria Noel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
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Fil: Monzani, María Cecili. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Aloisi Zavala, Natalia Andrea. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Gualtieri, Ariel Félix. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Corti, Marcelo. Fundacion de la Hemofilia; Argentina
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Fil: Parodi, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Pinto, Tezanos. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Primiani, Laura. Fundacion de la Hemofilia; Argentina
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Fil: Bracco, M. M. E. D.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
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Fil: Chuit, Roberto. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Epidemiológicas; Argentina
dc.description.fil
Fil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Japanese Journal of Gastroenterology and Hepatology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://jjgastrohepto.org/pdf/JJGH-v4-1370.pdf
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