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Artículo

Genetic susceptibility to life-threatening respiratory syncytial virus infection in previously healthy infants

Lopez, Eduardo Luis; Ferolla, Fausto MartínIcon ; Toledano, Analia; Yfran, Eduardo Walter; Giordano, Ana Clara; Carrizo, Bárbara; Feldman, Florencia; Talarico, Laura BeatrizIcon ; Caratozzolo, Ana; Contrini, María Marta; Acosta, Patricio LeandroIcon
Fecha de publicación: 07/2020
Editorial: Lippincott Williams
Revista: Pediatric Infectious Disease Journal
ISSN: 0891-3668
e-ISSN: 1532-0987
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Enfermedades Infecciosas

Resumen

Background: Genetic background may be an important host determinant of respiratory syncytial virus (RSV) disease severity, but full characterization of susceptibility genes remains unclear. This study aimed to assess the presence of specific single-nucleotide polymorphisms (SNPs) in selected genes codifying for different components of the antiviral innate immune response, to determine their role for developing RSV life-threatening disease (LTD). Methods: Prospective cohort study including previously healthy full-term infants hospitalized with a first RSV infection during 2017-2018. RSV detection, quantification and subgroup determination, and genotyping for SNPs in Toll-like receptor 4 (TLR4 rs4986790, rs4986791), Toll-like receptor 8 (TLR8 rs3761624), macrophage receptor with collagenous structure (MARCO rs1318645) and myxovirus resistance 1 (MX1 rs469390) were performed by real-time polymerase chain reaction in nasopharyngeal aspirates obtained on admission. Patients with LTD were those admitted to the intensive care unit requiring ventilatory support. Results: Seventy-five patients were studied, 15 (20%) developed LTD. Infants with concurrent SNPs in MX1 and TLR8, MARCO and TLR8 or MARCO, MX1 and TLR8 had an increased risk of developing LTD. Multivariable logistic regression analysis confirmed this significant association (odds ratio [OR] = 3.75, P = 0.046; OR = 3.92, P = 0.040; OR = 5.56, P = 0.010, respectively). No differences were seen in viral load of patients with LTD compared with those with better outcome (P = 0.737). In addition, no differences in viral load were seen in patients with the described high-risk SNPs compared with those without these polymorphisms. Conclusions: Life-threatening RSV infection in previously healthy infants was significantly associated with the presence of combined SNPs in MARCO, MX1 and TLR8.
Palabras clave: INFANTS , LIFE-THREATENING DISEASE , RESPIRATORY SYNCYTIAL VIRUS , SINGLE-NUCLEOTIDE POLYMORPHISMS
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/170106
URL: https://journals.lww.com/10.1097/INF.0000000000002827
DOI: http://dx.doi.org/10.1097/INF.0000000000002827
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Lopez, Eduardo Luis; Ferolla, Fausto Martín; Toledano, Analia; Yfran, Eduardo Walter; Giordano, Ana Clara; et al.; Genetic susceptibility to life-threatening respiratory syncytial virus infection in previously healthy infants; Lippincott Williams; Pediatric Infectious Disease Journal; 39; 11; 7-2020; 1057-1061
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