Mostrar el registro sencillo del ítem

dc.contributor.author
Blois, Sandra M.  
dc.contributor.author
Verlohren, Stefan  
dc.contributor.author
Wu, Gang  
dc.contributor.author
Clark, Gary  
dc.contributor.author
Dell, Anne  
dc.contributor.author
Haslam, Stuart M.  
dc.contributor.author
Barrientos, Gabriela Laura  
dc.date.available
2022-09-23T03:15:30Z  
dc.date.issued
2020-08  
dc.identifier.citation
Blois, Sandra M.; Verlohren, Stefan; Wu, Gang; Clark, Gary; Dell, Anne; et al.; Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB); Springer; Seminars in Immunopathology; 42; 4; 8-2020; 469-486  
dc.identifier.issn
1863-2297  
dc.identifier.uri
http://hdl.handle.net/11336/170102  
dc.description.abstract
Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
GALECTINS  
dc.subject
GLYCANS  
dc.subject
MICROBIAL INFECTIONS  
dc.subject
PRETERM BIRTH  
dc.subject.classification
Patología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-09-22T15:09:06Z  
dc.identifier.eissn
1863-2300  
dc.journal.volume
42  
dc.journal.number
4  
dc.journal.pagination
469-486  
dc.journal.pais
Alemania  
dc.description.fil
Fil: Blois, Sandra M.. Experimental and Clinical Research Center; Alemania. Charité-Universitätsmedizin Berlin; Alemania. University Medical Center Hamburg-Eppendorf; Alemania  
dc.description.fil
Fil: Verlohren, Stefan. Charité-Universitätsmedizin Berlin; Alemania  
dc.description.fil
Fil: Wu, Gang. Imperial College London; Reino Unido  
dc.description.fil
Fil: Clark, Gary. University of Missouri; Estados Unidos  
dc.description.fil
Fil: Dell, Anne. Imperial College London; Reino Unido  
dc.description.fil
Fil: Haslam, Stuart M.. Imperial College London; Reino Unido  
dc.description.fil
Fil: Barrientos, Gabriela Laura. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Seminars in Immunopathology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00281-020-00801-4  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00281-020-00801-4