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dc.contributor.author
Shimazu, Tomoyuki
dc.contributor.author
Villena, Julio Cesar
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dc.contributor.author
Tohno, Masanori
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Fujie, Hitomi
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Hosoya, Shoichi
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Shimosato, Takeshi
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Aso, Hisashi
dc.contributor.author
Suda, Yoshihito
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Kawai, Yasushi
dc.contributor.author
Saito, Tadao
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Makino, Seiya
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Ikegami, Shuji
dc.contributor.author
Itoh, Hiroyuki
dc.contributor.author
Kitazawa, Haruki
dc.date.available
2017-05-26T19:12:00Z
dc.date.issued
2012-01
dc.identifier.citation
Shimazu, Tomoyuki; Villena, Julio Cesar; Tohno, Masanori; Fujie, Hitomi; Hosoya, Shoichi; et al.; Immunobiotic Lactobacillus jensenii Elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway; American Society For Microbiology; Infection And Immunity; 80; 1; 1-2012; 276-288
dc.identifier.issn
0019-9567
dc.identifier.uri
http://hdl.handle.net/11336/16996
dc.description.abstract
The effect of Lactobacillus jensenii TL2937 on the inflammatory immune response triggered by enterotoxigenic Escherichia coli (ETEC) and lipopolysaccharide (LPS) in a porcine intestinal epitheliocyte cell line (PIE cells) was evaluated. Challenges with ETEC or LPS elicited toll-like receptor (TLR)-4-mediated inflammatory responses in cultured PIE cells, indicating that our cell line may be useful for studying inflammation in the guts of weaning piglets. In addition, we demonstrated that L. jensenii TL2937 attenuated the expression of pro-inflammatory cytokines and chemokines caused by ETEC or LPS challenge by downregulating TLR4-dependent nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) activation. Furthermore, we demonstrated that L. jensenii TL2937 stimulation of PIE cells upregulated three negative regulators of TLRs: A20, Bcl-3 and MPK-1, deepening the understanding of an immunobiotic mechanism of action. L. jensenii TL2937-mediated induction of negative regulators of TLRs would have a substantial physiological impact on homeostasis in PIE cells because excessive TLR inflammatory signaling would be downregulated. These results indicated that PIE cells can be used to study the mechanisms involved in the protective activity of immunobiotics against intestinal inflammatory damage and may provide useful information for the development of new immunologically functional feeds that help to prevent inflammatory intestinal disorders, including weaning-associated intestinal inflammation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society For Microbiology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lactobacillus Jensenii Tl2937
dc.subject
Porcine Intestinal Epithelial Cells
dc.subject
Toll-Like Receptor 4
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Anti-Inflammatory Activity
dc.subject.classification
Tecnologías que involucran la identificación de ADN, proteínas y enzimas, y cómo influyen en el conjunto de enfermedades y mantenimiento del bienestar
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dc.subject.classification
Biotecnología de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Immunobiotic Lactobacillus jensenii Elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-18T15:11:32Z
dc.identifier.eissn
1098-5522
dc.journal.volume
80
dc.journal.number
1
dc.journal.pagination
276-288
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington
dc.description.fil
Fil: Shimazu, Tomoyuki. Tohoku University. Graduate School of Agricultural Science. Food Immunology Group; Japón
dc.description.fil
Fil: Villena, Julio Cesar. Tohoku University. Graduate School of Agricultural Science. Food Immunology Group; Japón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
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Fil: Tohno, Masanori. National Institute Of Livestock And Grassland Science; Japón
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Fil: Fujie, Hitomi. Tohoku University. Graduate School of Agricultural Science. Food Immunology Group; Japón. Josai University. Graduate School of
Pharmaceutical Science. Department of Nutritional Physiology; Japón
dc.description.fil
Fil: Hosoya, Shoichi. Tohoku University. Graduate School of Agricultural Science. Food Immunology Group; Japón
dc.description.fil
Fil: Shimosato, Takeshi. Shinshu University. Fiber-Nanotech Young Researcher Empowerment Center; Japón
dc.description.fil
Fil: Aso, Hisashi. Tohoku University. Graduate School of Agricultural Science. Cell Biology Laboratory; Japón
dc.description.fil
Fil: Suda, Yoshihito. Miyagi University. Department of Food, Agriculture and Environmental Science; Japón
dc.description.fil
Fil: Kawai, Yasushi. Tohoku University. Graduate School of Agricultural Science. Food Immunology Group; Japón
dc.description.fil
Fil: Saito, Tadao. Tohoku University. Graduate School of Agricultural Science. Food Immunology Group; Japón
dc.description.fil
Fil: Makino, Seiya. Meiji Dairies Corporation. Division of Research and Development; Japón
dc.description.fil
Fil: Ikegami, Shuji. Meiji Dairies Corporation. Division of Research and Development; Japón
dc.description.fil
Fil: Itoh, Hiroyuki. Meiji Dairies Corporation. Division of Research and Development; Japón
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University. Graduate School of Agricultural Science. Food Immunology Group; Japón
dc.journal.title
Infection And Immunity
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/IAI.05729-11
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255675/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/80/1/276
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