Artículo
BLVector: Fast BLAST-Like Algorithm for Manycore CPU With Vectorization
Gálvez Rojas, Sergio; Agostini, Federico
; Caselli, Javier; Hernandez, Agustina Pilar; Dorado, Gabriel
Fecha de publicación:
02/2021
Editorial:
Frontiers Media
Revista:
Frontiers in Genetics
e-ISSN:
1664-8021
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
New High-Performance Computing architectures have been recently developed for commercial central processing unit (CPU). Yet, that has not improved the execution time of widely used bioinformatics applications, like BLAST+. This is due to a lack of optimization between the bases of the existing algorithms and the internals of the hardware that allows taking full advantage of the available CPU cores. To optimize the new architectures, algorithms must be revised and redesigned; usually rewritten from scratch. BLVector adapts the high-level concepts of BLAST+ to the x86 architectures with AVX-512, to harness their capabilities. A deep comprehensive study has been carried out to optimize the approach, with a significant reduction in time execution. BLVector reduces the execution time of BLAST+ when aligning up to mid-size protein sequences (∼750 amino acids). The gain in real scenario cases is 3.2-fold. When applied to longer proteins, BLVector consumes more time than BLAST+, but retrieves a much larger set of results. BLVector and BLAST+ are fine-tuned heuristics. Therefore, the relevant results returned by both are the same, although they behave differently specially when performing alignments with low scores. Hence, they can be considered complementary bioinformatics tools.
Palabras clave:
BENCHMARKING
,
DATABASE SEARCH
,
PAIRWISE ALIGNMENT
,
PARALLEL ALGORITHM
,
PROTEINS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBONE)
Articulos de INST.DE BOTANICA DEL NORDESTE (I)
Articulos de INST.DE BOTANICA DEL NORDESTE (I)
Citación
Gálvez Rojas, Sergio; Agostini, Federico; Caselli, Javier; Hernandez, Agustina Pilar; Dorado, Gabriel; BLVector: Fast BLAST-Like Algorithm for Manycore CPU With Vectorization; Frontiers Media; Frontiers in Genetics; 12; 2-2021; 1-10
Compartir
Altmétricas