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dc.contributor.author
de Freitas, Thiago  
dc.contributor.author
Zapaterini, Joyce R.  
dc.contributor.author
Moreira, Cristiane M.  
dc.contributor.author
de Aquino, Ariana M.  
dc.contributor.author
Alonso Costa, Luiz G.  
dc.contributor.author
Bidinotto, Lucas T.  
dc.contributor.author
Kass, Laura  
dc.contributor.author
Flaws, Jodi A.  
dc.contributor.author
Scarano, Wellerson R.  
dc.contributor.author
Barbisan, Luis F.  
dc.date.available
2022-09-21T14:09:53Z  
dc.date.issued
2021-10  
dc.identifier.citation
de Freitas, Thiago; Zapaterini, Joyce R.; Moreira, Cristiane M.; de Aquino, Ariana M.; Alonso Costa, Luiz G.; et al.; Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring; Pergamon-Elsevier Science Ltd; Food and Chemical Toxicology; 156; 10-2021; 1-9  
dc.identifier.issn
0278-6915  
dc.identifier.uri
http://hdl.handle.net/11336/169715  
dc.description.abstract
Phthalates metabolites have been detected in the urine of pregnant and breastfeeding women. Thus, this study evaluated the adverse effects of maternal exposure to a mixture of six phthalates (Pth mix) on the mammary gland development and carcinogenesis in F1 female offspring. Pregnant female Sprague-Dawley rats were exposed daily to vehicle or Pth mix (35.22% diethyl-phthalate, 21.03% di-(2-ethylhexyl)-phthalate, 14.91% dibutyl-phthalate, 15.10% diisononyl-phthalate, 8.61% diisobutyl-phthalate, and 5.13% benzylbutyl-phthalate) by gavage at 20 μg/kg, 200 μg/kg or 200 mg/kg during gestational day 10 (GD 10) to postnatal day 21 (PND 21). After weaning (PND 22), some female offspring were euthanized for mammary gland analyses while other females received a single dose of N-methyl-N-nitrosourea (MNU, 50 mg/kg) or vehicle and then tumor incidence and multiplicity were recorded until PND 180. Maternal Pth mix exposure increased the number of Ki-67 and progesterone receptor-positive epithelial cells in the mammary gland from Pth mix 200 at μg/kg and 200 mg/kg groups. In addition, tumor incidence and mean number were higher only in Pth mix at 200 mg/kg when compared to the vehicle-treated group, and percentage of tumor-free animals was lower in Pth mix at 200 μg/kg and 200 mg/kg groups. The findings indicate that perinatal Pth mixture exposure increased susceptibility to MNU-induced mammary carcinogenesis in adult F1 female offspring.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CHEMICALLY-INDUCED MAMMARY TUMOR  
dc.subject
F1FEMALE OFFSPRING  
dc.subject
MAMMARY GLAND DEVELOPMENT AND CANCER SUSCEPTIBILITY  
dc.subject
PHTHALATE MIXTURE  
dc.subject.classification
Toxicología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-09-19T15:00:29Z  
dc.journal.volume
156  
dc.journal.pagination
1-9  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: de Freitas, Thiago. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil  
dc.description.fil
Fil: Zapaterini, Joyce R.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil  
dc.description.fil
Fil: Moreira, Cristiane M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil  
dc.description.fil
Fil: de Aquino, Ariana M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil  
dc.description.fil
Fil: Alonso Costa, Luiz G.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil  
dc.description.fil
Fil: Bidinotto, Lucas T.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil  
dc.description.fil
Fil: Kass, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina  
dc.description.fil
Fil: Flaws, Jodi A.. University of Illinois. Urbana - Champaign; Estados Unidos  
dc.description.fil
Fil: Scarano, Wellerson R.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil  
dc.description.fil
Fil: Barbisan, Luis F.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil  
dc.journal.title
Food and Chemical Toxicology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0278691521005524  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.fct.2021.112519