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dc.contributor.author
Urzúa Pizarro, Natala Francisca
dc.contributor.author
Messina, María Jimena
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Caverzan, Matias Daniel
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Prieto, Guillermo Fermín
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Lüders, Carlos
dc.contributor.author
Errecalde, Carlos
dc.date.available
2022-09-20T14:05:54Z
dc.date.issued
2020-07
dc.identifier.citation
Urzúa Pizarro, Natala Francisca; Messina, María Jimena; Caverzan, Matias Daniel; Prieto, Guillermo Fermín; Lüders, Carlos; et al.; Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs; Taylor & Francis Ltd; Xenobiotica; 7-2020; 1490-1493
dc.identifier.issn
0049-8254
dc.identifier.uri
http://hdl.handle.net/11336/169561
dc.description.abstract
The study aims to establish the plasma pharmacokinetic parameters of levofloxacin in mixed-breed dogs, at a single dose of 5 mg/kg, intravenously, orally only and orally with sucralfate pre-treatment (1 g per animal), to evaluate its influence on antimicrobial absorption. Concentrations of levofloxacin in plasma were determined using high-performance liquid chromatography (HPLC) with fluorescence detection. After iv of levofloxacin, the mean (±SD) of AUC0–24, Vz, t½λz and MRT, was 19.05 ± 6.4 µg-h/ml, 2.43 ± 0.5 L/kg, 7.93 ± 1.41 hours and 8.7 ± 1.5 hours, respectively. After oral administration, the C max, t½λz and bioavailability were 1.95 ± 0.7 µg/ml, 7.65 ± 1.38 hours and 71.93 ± 9.75%, respectively. In animals given an oral dose of levofloxacin with sucralfate pre-treatment, there was a significant decrease (p < 0.05) in C max (0.57 ± 0.23 µg/ml), AUC (5.73 ± 2.26 µg-h/ml) and bioavailability (31.92 ± 14.19%). In the dogs studied, it is suggested that the dose 5 mg/kg of levofloxacin for both routes is inadequate to meet PK–PD targets for susceptible bacteria using breakpoints established by the Institute of Clinical and Laboratory Standards (CLSI).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DOGS
dc.subject
LEVOFLOXACIN
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PHARMACOKINETICS
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SUCRALFATE
dc.subject.classification
Otras Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-19T20:36:34Z
dc.journal.pagination
1490-1493
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Urzúa Pizarro, Natala Francisca. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Clinica Animal. Área de Cirugía Experimental.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Messina, María Jimena. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Clinica Animal. Área de Cirugía Experimental.; Argentina
dc.description.fil
Fil: Caverzan, Matias Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Prieto, Guillermo Fermín. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Clinica Animal. Área de Cirugía Experimental.; Argentina
dc.description.fil
Fil: Lüders, Carlos. Universidad Católica de Temuco; Chile
dc.description.fil
Fil: Errecalde, Carlos. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Clinica Animal. Área de Cirugía Experimental.; Argentina
dc.journal.title
Xenobiotica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/00498254.2020.1793031
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/00498254.2020.1793031
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