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Artículo

Neutron autoradiography to study the microdistribution of boron in the lung

Espain, Maria SolIcon ; Dattoli Viegas, Ana MailenIcon ; Trivillin, Verónica AndreaIcon ; Saint Martin, María Laura Gisela; Thorp, Silvia Inés; Curotto, Paula; Pozzi, Emiliano César Cayetano; González, Sara JosefinaIcon ; Portu, Agustina MarianaIcon
Fecha de publicación: 11/2020
Editorial: Pergamon-Elsevier Science Ltd
Revista: Applied Radiation and Isotopes
ISSN: 0969-8043
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Físicas

Resumen

In Argentina, a multi-institutional project has been established to assess the feasibility of applying BNCT ex-situ to the treatment of patients with multiple metastases in both lungs. Within this context, this work aims at applying the neutron autoradiography technique to study boron microdistribution in the lung. A comprehensive analysis of the different aspects for the generation of autoradiographic images of both normal and metastatic BDIX rat lungs was achieved. Histology, boron uniformity, optimal tissue thickness and water content in tissue were explored for the two types of samples. A qualitative and a quantitative analysis were performed. No heterogeneities in uptake were observed in normal lung. Conversely, samples with metastasis showed preferential boron uptake in the tumour areas with respect to surrounding tissue. Surrounding tissue would present a slightly higher uptake of boron than the normal lung. Quantitative results of boron concentration values and ratios determined by neutron autoradiography were obtained. In order to contribute to BNCT dosimetry, further analysis increasing the number of samples is warranted.
Palabras clave: BNCT , BORON MICRODISTRIBUTION , LUNG , NEUTRON AUTORADIOGRAPHY , NUCLEAR TRACK DETECTORS
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/169538
URL: https://linkinghub.elsevier.com/retrieve/pii/S0969804320304814
DOI: http://dx.doi.org/10.1016/j.apradiso.2020.109331
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Espain, Maria Sol; Dattoli Viegas, Ana Mailen; Trivillin, Verónica Andrea; Saint Martin, María Laura Gisela; Thorp, Silvia Inés; et al.; Neutron autoradiography to study the microdistribution of boron in the lung; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 165; 11-2020; 1-8
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