Mostrar el registro sencillo del ítem
dc.contributor.author
Grandjean, Louis
dc.contributor.author
Monteserin, Johana
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Gilman, Robert
dc.contributor.author
Pauschardt, Julia
dc.contributor.author
Rokadiya, Sakib
dc.contributor.author
Bonilla, Cesar
dc.contributor.author
Ritacco, Gloria Viviana
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Vidal, Julia Rios
dc.contributor.author
Parkhill, Julian
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Peacock, Sharon
dc.contributor.author
Vidal, Julia Rios
dc.contributor.author
Balloux, Francois
dc.date.available
2022-09-16T15:00:06Z
dc.date.issued
2020-07
dc.identifier.citation
Grandjean, Louis; Monteserin, Johana; Gilman, Robert; Pauschardt, Julia; Rokadiya, Sakib; et al.; Association between bacterial homoplastic variants and radiological pathology in tuberculosis; B M J Publishing Group; Thorax.; 75; 7; 7-2020; 584-591
dc.identifier.issn
0040-6376
dc.identifier.uri
http://hdl.handle.net/11336/169102
dc.description.abstract
Background: Understanding how pathogen genetic factors contribute to pathology in TB could enable tailored treatments to the most pathogenic and infectious strains. New strategies are needed to control drug-resistant TB, which requires longer and costlier treatment. We hypothesised that the severity of radiological pathology on the chest radiograph in TB disease was associated with variants arising independently, multiple times (homoplasies) in the Mycobacterium tuberculosis genome. Methods: We performed whole genome sequencing (Illumina HiSeq2000 platform) on M. tuberculosis isolates from 103 patients with drug-resistant TB in Lima between 2010 and 2013. Variables including age, sex, HIV status, previous TB disease and the percentage of lung involvement on the pretreatment chest radiograph were collected from health posts of the national TB programme. Genomic variants were identified using standard pipelines. Results: Two mutations were significantly associated with more widespread radiological pathology in a multivariable regression model controlling for confounding variables (Rv2828c.141, RR 1.3, 95% CI 1.21 to 1.39, p<0.01; rpoC.1040 95% CI 1.77 to 2.16, RR 1.9, p<0.01). The rpoB.450 mutation was associated with less extensive radiological pathology (RR 0.81, 95% CI 0.69 to 0.94, p=0.03), suggestive of a bacterial fitness cost for this mutation in vivo. Patients with a previous episode of TB disease and those between 10 and 30 years of age also had significantly increased radiological pathology. Conclusions: This study is the first to compare the M. tuberculosis genome to radiological pathology on the chest radiograph. We identified two variants significantly positively associated with more widespread radiological pathology and one with reduced pathology. Prospective studies are warranted to determine whether mutations associated with increased pathology also predict the spread of drug-resistant TB.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
B M J Publishing Group
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CLINICAL EPIDEMIOLOGY
dc.subject
IMAGING/CT MRI ETC
dc.subject
TUBERCULOSIS
dc.subject.classification
Enfermedades Infecciosas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias de la Salud
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Association between bacterial homoplastic variants and radiological pathology in tuberculosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-15T14:57:22Z
dc.journal.volume
75
dc.journal.number
7
dc.journal.pagination
584-591
dc.journal.pais
Reino Unido
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Londres
dc.description.fil
Fil: Grandjean, Louis. Imperial College London; Reino Unido
dc.description.fil
Fil: Monteserin, Johana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gilman, Robert. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Pauschardt, Julia. Universidad Cayetano Heredia; Perú
dc.description.fil
Fil: Rokadiya, Sakib. Imperial College London; Reino Unido
dc.description.fil
Fil: Bonilla, Cesar. Ministerio de Salud; Perú
dc.description.fil
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Vidal, Julia Rios. Ministerio de Salud; Perú
dc.description.fil
Fil: Parkhill, Julian. Wellcome Trust Sanger Institute; Reino Unido
dc.description.fil
Fil: Peacock, Sharon. University of Cambridge; Reino Unido
dc.description.fil
Fil: Vidal, Julia Rios. London School Of Hygiene And Tropical Medicine; Reino Unido
dc.description.fil
Fil: Balloux, Francois. University College London; Estados Unidos
dc.journal.title
Thorax.
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-213281
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1136/thoraxjnl-2019-213281
Archivos asociados