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dc.contributor.author
Barrantes, Francisco Jose
dc.date.available
2022-09-16T14:36:22Z
dc.date.issued
2021-06
dc.identifier.citation
Barrantes, Francisco Jose; Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol; Instituto de Histología y Embriología; Biocell; 45; 6; 6-2021; 1479-1484
dc.identifier.issn
0327-9545
dc.identifier.uri
http://hdl.handle.net/11336/169081
dc.description.abstract
Cholesterol is a major lipid in biological membranes. It not only plays a structural role but also modulates a wide range of functional properties of neurotransmitter and hormone receptors and ion channels. The membraneembedded segments of the paradigm neurotransmitter receptor for acetylcholine (nAChR) contain linear sequences of amino acids with the capacity to recognize cholesterol. These cholesterol consensus domains have been designated as "CARC" and its mirror sequence "CRAC". CARC preferentially occurs in the exoplasmic-facing membrane leaflet, and CRAC, in the cytoplasmic-facing hemilayer. Both motifs are highly conserved among ion-channel and neurotransmitter receptor proteins in vertebrate nervous systems, where they recognize cholesterol, and in prokaryotic homologues in bacteria, where they recognize hopanoids. This phylogenetically conserved trait is an indication that the hopanoids in some bacteria and cholesterol in eukaryotes subserve analogous functions, probably contributing to the stability of membrane-embedded protein domains. Structural studies from our laboratory using superresolution optical microscopy ("nanoscopy") have disclosed other interrelated functional and structural properties exerted by cholesterol on the nAChR. The neutral lipid content at the cell surface influences both the macromolecular organization of the receptor and its translational mobility (diffusion) in the plane of the membrane.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Instituto de Histología y Embriología
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CHOLESTEROL
dc.subject
CHOLESTEROL-RECOGNITION DOMAINS
dc.subject
EVOLUTION
dc.subject
MEMBRANE PROTEINS
dc.subject
NANOSCOPY
dc.subject
NICOTINIC ACETYLCHOLINE RECEPTOR
dc.subject
PENTAMERIC LIGAND-GATED ION CHANNEL
dc.subject.classification
Biofísica
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-09T17:22:42Z
dc.journal.volume
45
dc.journal.number
6
dc.journal.pagination
1479-1484
dc.journal.pais
Argentina
dc.description.fil
Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
Biocell
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.32604/biocell.2021.016502
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/biocell/v45n6/44279
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