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dc.contributor.author
Malirat, Viviana
dc.contributor.author
Bergmann, Ingrid Evelyn
dc.contributor.author
Campos, Renata de Mendonça
dc.contributor.author
Conde, Florangel
dc.contributor.author
Quiroga, José Luis
dc.contributor.author
Villamil, Mariluz
dc.contributor.author
Salgado, Gustavo
dc.contributor.author
Ortiz, Salomón
dc.date.available
2017-05-23T19:45:28Z
dc.date.issued
2012-07
dc.identifier.citation
Malirat, Viviana; Bergmann, Ingrid Evelyn; Campos, Renata de Mendonça; Conde, Florangel; Quiroga, José Luis; et al.; Molecular epidemiology of foot-and-mouth disease virus type A in South America; Elsevier Science; Veterinary Microbiology; 158; 1-2; 7-2012; 82-94
dc.identifier.issn
0378-1135
dc.identifier.uri
http://hdl.handle.net/11336/16895
dc.description.abstract
A databank of 78 VP1 complete sequences of type A foot-and-mouth disease virus (FMDV) from South American isolates was constructed. Forty-nine samples corresponded to FMDV that circulated between the years 1999–2008, mainly in Venezuela, where most type A outbreaks have occurred lately and twenty-nine to strains historically relevant for the continent. The phylogenetic analysis showed that all South American FMDV belonged to the Euro-SA topotype. Sixteen subgenotypes could be identified, based on a 15% nucleotide divergence cut-off criterion: eight are extinguished, three were active until the year 2002 and the remaining five circulated in Venezuela during the years 2001–2007, illustrating the potential for FMDV diversification under appropriate selective pressure. The last emergencies reported in already-free areas of Colombia in 2004 and 2008 were closely related to isolates acting in Venzuela. Evidence of positive selection over codon 170, within the immunogenic site 4 of VP1 protein, was recorded. A codon deletion in amino acid position 142, within the G–H loop, was found in some isolates within subgenotypes 14, 15 and 16. Conversely amino acid deletion 197 was restricted to all isolates within a particular genetic cluster. The present work is the first comprehensive phylogenetic analysis of FMDV type A in South America, filling a gap of knowledge with respect to both, historical and acting viruses. The results provided evidence that supports the ecosystem dynamics in the region, and also served as an input to establish genetic links of emergencies in already-declared free areas, highlighting the need for strengthening control activities.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Foot-And-Mouth Disease Type a Virus
dc.subject
Molecular Epidemiology
dc.subject
Sequence Analysis
dc.subject
Europesouth America Fmdv Topotype
dc.subject.classification
Otras Ciencias Veterinarias
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Molecular epidemiology of foot-and-mouth disease virus type A in South America
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-22T20:48:36Z
dc.journal.volume
158
dc.journal.number
1-2
dc.journal.pagination
82-94
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Malirat, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. Cesar Milstein". Fundación Pablo Cassara. Instituto de Ciencia y Tecnología ; Argentina. Pan American Foot-and-Mouth Disease Center; Brasil
dc.description.fil
Fil: Bergmann, Ingrid Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. Cesar Milstein". Fundación Pablo Cassara. Instituto de Ciencia y Tecnología ; Argentina. Pan American Foot-and-Mouth Disease Center; Brasil
dc.description.fil
Fil: Campos, Renata de Mendonça. Pan American Foot-and-Mouth Disease Center; Brasil. Instituto Oswaldo Cruz; Brasil
dc.description.fil
Fil: Conde, Florangel. Centro Nacional de Investigaciones Agropecuarias. Instituto Nacional de Investigaciones Agrícolas; Venezuela
dc.description.fil
Fil: Quiroga, José Luis. Laboratorio de Investigación y Diagnóstico Veterinario; Bolivia
dc.description.fil
Fil: Villamil, Mariluz. Laboratorio Nacional de Diagnóstico Veterinario; Colombia
dc.description.fil
Fil: Salgado, Gustavo. Instituto de Medicina e Higiene Tropical ‘‘Izquieta Perez’; Ecuador
dc.description.fil
Fil: Ortiz, Salomón. Servicio Nacional de Sanidad Animal; Perú
dc.journal.title
Veterinary Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vetmic.2012.02.009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0378113512001198
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