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dc.contributor.author
Corominas, Ana Irene
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Balconi, Silvia
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Ortiz, Maria
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Maskin, Bernardo
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Damiano, Alicia Ermelinda
dc.date.available
2022-09-15T10:48:59Z
dc.date.issued
2019
dc.identifier.citation
Uric acid levels in gestational hypertensive disorders and fetal growth restriction; International Federation of Placenta Association Meeting; Ciudad Autonoma de Buenos Aires; Argentina; 2019; 1-1
dc.identifier.issn
0143-4004
dc.identifier.uri
http://hdl.handle.net/11336/168813
dc.description.abstract
Objectives: To evaluate the levels of serum uric acid in pregnant womenwith fetal growth restriction associated or not with hypertensivedisorders.Methods: A retrospective descriptive-quantitative study was carried out inall women who attended their pregnancy at the Hospital Posadas during2014. Newborn of singleton pregnancies with fetal growth restriction(IUGR) and more than 22 weeks were studied. Uricemia ratio (uricemiaafter 20th week /uricemia before 20th week) was calculated in women whopresented IUGR associated or not to preeclampsia (PE) and gestationalhypertension (PIH).Results: In 3589 simple gestations analyzed, 100 presented PE (24 withIUGR), 208 PIH (19 with IUGR) and 3281 were normotensive (203 withIUGR).In the hypertensive group, the relative risk (RR) of having a newbornunder percentile 10 was 4.09(2.82-5.94) for PE and 1.72(1.12-2.64) for PIH.Regarding the evolution of pregnancy and birth, PE women have thehighest RR of prematurity, pathological Doppler, newborn weight <2500and requirement for neonatal intensive care at birth, while the RR foroligohydramnios was higher in PIH than in PE [2.1(1.02-3.94) vs 2.58 (1.45-4.60)]. Uricemia ratio was significantly increased in women with preeclampsia(1.77±0.28 in PE, 1.26±0.31 in PIH, 1.20±0.28 in normotensivewomen). The association between hypertension and IUGR increased theselevels (2.18±0.68 in PE and 1.6±0.50 in PIH). Uricemia ratio in normotensivewomen with IUGR was unchanged (1.21±0.29).Conclusion: Our results showed that normotensive pregnancies with orwithout growth restriction are not associated with an increase in uricemialevels. However, in gestational hypertensive disorders accompanying withfetal growth restriction the high increase in uricemia seems to be related toa more severe presentation of the maternal endothelial dysfunction. Thesefindings suggest that the etiology of the insufficient placentation in thesesyndromes may be different.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
URIC ACID
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PREECLAMPSIA
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IUGR
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Uric acid levels in gestational hypertensive disorders and fetal growth restriction
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2021-07-07T15:16:41Z
dc.journal.pagination
1-1
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Corominas, Ana Irene. Hospital Nacional Profesor Alejandro Posadas; Argentina
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Fil: Balconi, Silvia. Hospital Nacional Profesor Alejandro Posadas; Argentina
dc.description.fil
Fil: Ortiz, Maria. Hospital Nacional Profesor Alejandro Posadas; Argentina
dc.description.fil
Fil: Maskin, Bernardo. Hospital Nacional Profesor Alejandro Posadas; Argentina
dc.description.fil
Fil: Damiano, Alicia Ermelinda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0143400419304564
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.placenta.2019.06.327
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Autor
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Autor
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Autor
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Autor
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Autor
dc.coverage
Internacional
dc.type.subtype
Reunión
dc.description.nombreEvento
International Federation of Placenta Association Meeting
dc.date.evento
2019-09-10
dc.description.ciudadEvento
Ciudad Autonoma de Buenos Aires
dc.description.paisEvento
Argentina
dc.type.publicacion
Journal
dc.description.institucionOrganizadora
International Federation of Placenta Associations
dc.source.revista
Placenta
dc.date.eventoHasta
2019-09-13
dc.type
Reunión
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