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dc.contributor.author
Bagatolli, Luis Alberto
dc.contributor.author
Stock, Roberto
dc.date.available
2022-09-15T10:35:51Z
dc.date.issued
2021-10
dc.identifier.citation
Bagatolli, Luis Alberto; Stock, Roberto; Lipids, membranes, colloids and cells: A long view; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1863; 10; 10-2021; 1-28
dc.identifier.issn
0005-2736
dc.identifier.uri
http://hdl.handle.net/11336/168809
dc.description.abstract
This paper revisits long-standing ideas about biological membranes in the context of an equally long-standing, but hitherto largely unappreciated, perspective of the cell based on concepts derived from the physics and chemistry of colloids. Specifically, we discuss important biophysical aspects of lipid supramolecular structure to understand how the intracellular milieu may constrain lipid self-assembly. To this end we will develop four lines of thought: first, we will look at the historical development of the current view of cellular structure and physiology, considering also the plurality of approaches that influenced its formative period. Second, we will review recent basic research on the structural and dynamical properties of lipid aggregates as well as the role of phase transitions in biophysical chemistry and cell biology. Third, we will present a general overview of contemporary studies into cellular compartmentalization in the context of a very rich and mostly forgotten general theory of cell physiology called the Association-Induction Hypothesis, which was developed around the time that the current view of cells congealed into its present form. Fourth, we will examine some recent developments in cellular studies, mostly from our laboratory, that raise interesting issues about the dynamical aspects of cell structure and compartmentalization. We will conclude by suggesting what we consider are relevant questions about the nature of cellular processes as emergent phenomena.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ASSOCIATION INDUCTION HYPOTHESIS
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BIOLOGICAL MEMBRANE MODELS
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CELLULAR MODELS
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LIQUID-LIQUID PHASE TRANSITIONS
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LYOTROPIC MESOMORPHISM
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MACROMOLECULAR CROWDING
dc.subject.classification
Biofísica
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Lipids, membranes, colloids and cells: A long view
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-30T14:29:43Z
dc.identifier.eissn
1879-2642
dc.journal.volume
1863
dc.journal.number
10
dc.journal.pagination
1-28
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Bagatolli, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Memphys - International And Interdisciplinary Research Network; Dinamarca. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina
dc.description.fil
Fil: Stock, Roberto. Memphys - International And Interdisciplinary Research Network; Dinamarca
dc.journal.title
Biochimica et Biophysica Acta - Biomembranes
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0005273621001346?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbamem.2021.183684
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