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dc.contributor.author
Sarasola, María de la Paz
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Táquez Delgado, Mónica Alejandra
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Nicoud, Melisa Beatriz
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Medina, Vanina Araceli
dc.date.available
2022-09-15T10:34:27Z
dc.date.issued
2021-10
dc.identifier.citation
Sarasola, María de la Paz; Táquez Delgado, Mónica Alejandra; Nicoud, Melisa Beatriz; Medina, Vanina Araceli; Histamine in cancer immunology and immunotherapy. Current status and new perspectives; John Wiley & Sons Inc.; Pharmacology Research and Perspectives; 9; 5; 10-2021; 1-28
dc.identifier.issn
2052-1707
dc.identifier.uri
http://hdl.handle.net/11336/168808
dc.description.abstract
Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront of cancer treatments, resulting in impressive and durable responses but only in a fraction of patients. Thus, understanding the characteristics and profiles of immune cells in the tumor microenvironment (TME) is a necessary step to move forward in the design of new immunomodulatory strategies that can boost the immune system to fight cancer. Histamine produces a complex and fine-tuned regulation of the phenotype and functions of the different immune cells, participating in multiple regulatory responses of the innate and adaptive immunity. Considering the important actions of histamine-producing immune cells in the TME, in this review we first address the most important immunomodulatory roles of histamine and histamine receptors in the context of cancer development and progression. In addition, this review highlights the current progress and foundational developments in the field of cancer immunotherapy in combination with histamine and pharmacological compounds targeting histamine receptors.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ADAPTIVE IMMUNITY
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ANTI-TUMOR IMMUNITY
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BREAST CANCER
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HISTAMINE RECEPTORS
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IMMUNOTHERAPY
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INNATE IMMUNITY
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LEUKEMIA
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Histamine in cancer immunology and immunotherapy. Current status and new perspectives
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-07T18:24:59Z
dc.journal.volume
9
dc.journal.number
5
dc.journal.pagination
1-28
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Sarasola, María de la Paz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Táquez Delgado, Mónica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Nicoud, Melisa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
Pharmacology Research and Perspectives
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/prp2.778
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info:eu-repo/semantics/altIdentifier/url/https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/prp2.778
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