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Artículo

Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer's Disease Neuroimaging Initiative

Allegri, Ricardo FranciscoIcon ; Chrem Mendez, Patricio Alexis; Calandri, Ismael; Cohen, Gabriela; Martin, María Eugenia; Russo, María JulietaIcon ; Crivelli, Lucía; Pertierra, Lucia; Tapajóz, Fernanda; Clarens, María Florencia; Campos Tapia, Jorge Andrés; Nahas, Federico ExequielIcon ; Díaz Vázquez, María Silvia Johanna; Surace, Ezequiel IgnacioIcon ; Sevlever, Gustavo
Fecha de publicación: 19/05/2020
Editorial: Wiley-liss, div John Wiley & Sons Inc.
Revista: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
ISSN: 2352-8729
e-ISSN: 2352-8729
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Psicología

Resumen

Purpose: To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in the Argentine-Alzheimer's Disease Neuroimaging Initiative (arg-ADNI) cohort. Methods: Twenty-three patients with mild cognitive impairment (MCI), 12 dementia of Alzheimer's type (DAT), and 14 normal controls were studied following the ADNI2 protocol. Patients were categorized according to presence or absence of the biomarkers for amyloid beta (Aβ; A: amyloid positron emission tomography [PET] scan or cerebrospinal fluid [CSF] Aβ42), tau (T: CSF phosphorylated-tau), and neurodegeneration (N: CSF total-tau, fluorodeoxyglucose [FDG]-PET scan, or structural magnetic resonance imaging [MRI] scan). Results: A+T+N+ biomarker profile was identified at baseline in 91% of mild dementia patients, 20% of early MCI patients, 46% of late MCI patients, and 14% of control subjects. Suspected non-AD pathophysiology (SNAP, A-T-N+) was found in 8% of mild dementia, 20% of early MCI, 15% of late MCI, and 7% of control subjects. Conversion rates to dementia after 5-year follow-up were 85% in A+T+N+ MCI patients and 50% in A-T-N+ patients. Conclusions: We present initial 5-year follow-up results of a regional ADNI based on AD biomarkers and the ATN classification.
Palabras clave: ALZHEIMER'S DISEASE , AMYLOID , BIOMARKERS , CLASSIFICATION , NEURODEGENERATION , TAU
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
URI: http://hdl.handle.net/11336/168792
URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/dad2.12026
DOI: http://dx.doi.org/10.1002/dad2.12026
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Allegri, Ricardo Francisco; Chrem Mendez, Patricio Alexis; Calandri, Ismael; Cohen, Gabriela; Martin, María Eugenia; et al.; Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer's Disease Neuroimaging Initiative; Wiley-liss, div John Wiley & Sons Inc.; Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring; 12; 1; 19-5-2020; 1-8
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