Mostrar el registro sencillo del ítem
dc.contributor.author
Koabel, Jennifer
dc.contributor.author
McNivens, Meghan
dc.contributor.author
McKee, Paul
dc.contributor.author
Pautassi, Ricardo Marcos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Bordner, Kelly
dc.contributor.author
Nizhnikov, Michael
dc.date.available
2022-09-14T17:36:52Z
dc.date.issued
2021-05
dc.identifier.citation
Koabel, Jennifer; McNivens, Meghan; McKee, Paul; Pautassi, Ricardo Marcos; Bordner, Kelly; et al.; The offspring of alcohol-exposed sires exhibit heightened ethanol intake and behavioral alterations in the elevated plus maze; Elsevier Science Inc.; Alcohol; 92; 5-2021; 65-72
dc.identifier.issn
0741-8329
dc.identifier.uri
http://hdl.handle.net/11336/168734
dc.description.abstract
Research suggests that addictive traits are indeed heritable, but very few preclinical studies have explored transgenerational effects of paternal alcohol exposure. The present study addressed this gap in knowledge. We explored whether offspring of ethanol-exposed sires would be more likely to accept ethanol than descendants of water-exposed and control sires. We also investigated whether the second generation of ethanol-exposed descendants would accept ethanol more than controls and were more or less likely to experience anxiety-like behavior in behavioral assessments. We exposed male rats to repeated binge doses of alcohol (4 g/kg/day across 8 days), water, or left them untreated and mated them with untreated females. We then bred the offspring of these rats to test transgenerational effects of paternal alcohol exposure. We tested 14-day-old offspring from the first and second filial generation for their acceptance of ethanol and water, and measured anxiety-like behavior in 38-day-old, second-generation offspring using an elevated plus maze. The results indicate that offspring of ethanol-exposed sires increase ethanol acceptance in the first generation compared to untreated controls, whereas in the second-generation increased ethanol acceptance vs. these controls is seen in descendants of both ethanol- and vehicle-treated sires. At adolescence, the second generation of rats derived from alcohol-exposed sires exhibited significantly more time spent in the open arms and significantly more arm entries than any other group. The present study suggests that parental ethanol exposure is associated with lingering effects in the infant and adolescent offspring. The second filial generation was also found to be affected, albeit similarly by grandparental ethanol exposure or by the stress of the vehicle administration.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc.
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ETHANOL
dc.subject
INHIBITORY CONTROL
dc.subject
PATERNAL EXPOSURE
dc.subject
TRANSGENERATIONAL
dc.subject.classification
Drogadicción
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias de la Salud
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
The offspring of alcohol-exposed sires exhibit heightened ethanol intake and behavioral alterations in the elevated plus maze
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-30T14:30:06Z
dc.journal.volume
92
dc.journal.pagination
65-72
dc.journal.pais
Países Bajos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Koabel, Jennifer. State University of New York. Stony Brook University; Estados Unidos
dc.description.fil
Fil: McNivens, Meghan. State University of New York. Stony Brook University; Estados Unidos
dc.description.fil
Fil: McKee, Paul. Southern Connecticut State University; Estados Unidos
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Bordner, Kelly. Southern Connecticut State University; Estados Unidos
dc.description.fil
Fil: Nizhnikov, Michael. Southern Connecticut State University; Estados Unidos
dc.journal.title
Alcohol
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0741832921000161
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.alcohol.2021.01.009
Archivos asociados