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dc.contributor.author
Hoffiz, Yarely C.
dc.contributor.author
Castillo Ruiz, Alexandra
dc.contributor.author
Hall, Megan A. L.
dc.contributor.author
Hite, Taylor A.
dc.contributor.author
Gray, Jennifer M.
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Cisternas, Carla Daniela
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Cortes, Laura R.
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Jacobs, Andrew J.
dc.contributor.author
Forger, Nancy G.
dc.date.available
2022-09-14T17:21:48Z
dc.date.issued
2021-12
dc.identifier.citation
Hoffiz, Yarely C.; Castillo Ruiz, Alexandra; Hall, Megan A. L.; Hite, Taylor A.; Gray, Jennifer M.; et al.; Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death; Nature Publishing Group; Scientific Reports; 11; 1; 12-2021; 1-14
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/168729
dc.description.abstract
Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activation of the suprachiasmatic, supraoptic, and paraventricular nuclei of the hypothalamus. This was seen whether mice were born vaginally or via Cesarean section (C-section), and when birth timing was experimentally manipulated. Neuronal phenotyping showed that the activated neurons were predominantly vasopressinergic, and vasopressin mRNA increased fivefold in the hypothalamus during the 2–3 days before birth. Copeptin, a surrogate marker of vasopressin, was elevated 30-to 50-fold in plasma of perinatal mice, with higher levels after a vaginal than a C-section birth. We also found an acute decrease in plasma osmolality after a vaginal, but not C-section birth, suggesting that the difference in vasopressin release between birth modes is functionally meaningful. When vasopressin was administered centrally to newborns, we found an ~ 50% reduction in neuronal cell death in specific brain areas. Collectively, our results identify a conserved neuroendocrine response to birth that is sensitive to birth mode, and influences peripheral physiology and neurodevelopment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
VASOPRESSIN
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VAGINAL BIRTH
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CESAREAN SECTION
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NEURAL ACTIVATION
dc.subject.classification
Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-30T14:30:01Z
dc.journal.volume
11
dc.journal.number
1
dc.journal.pagination
1-14
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Hoffiz, Yarely C.. Georgia State University; Estados Unidos
dc.description.fil
Fil: Castillo Ruiz, Alexandra. Georgia State University; Estados Unidos
dc.description.fil
Fil: Hall, Megan A. L.. Georgia State University; Estados Unidos
dc.description.fil
Fil: Hite, Taylor A.. Georgia State University; Estados Unidos
dc.description.fil
Fil: Gray, Jennifer M.. Georgia State University; Estados Unidos
dc.description.fil
Fil: Cisternas, Carla Daniela. Georgia State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Cortes, Laura R.. Georgia State University; Estados Unidos
dc.description.fil
Fil: Jacobs, Andrew J.. Georgia State University; Estados Unidos
dc.description.fil
Fil: Forger, Nancy G.. Georgia State University; Estados Unidos
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-021-81511-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-021-81511-1
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