Artículo
Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections
Fecha de publicación:
05/2020
Editorial:
Hindawi Publishing Corporation
Revista:
Journal of Immunology Research
ISSN:
2314-8861
e-ISSN:
2314-7156
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Type I interferons (IFN-I) are a group of related proteins that help regulate the activity of the immune system and play a key role in host defense against viral infections. Upon infection, the IFN-I are rapidly secreted and induce a wide range of effects that not only act upon innate immune cells but also modulate the adaptive immune system. While IFN-I and many IFN stimulated genes are well-known for their protective antiviral role, recent studies have associated them with potential pathogenic functions. In this review, we summarize the current knowledge regarding the complex effects of human IFN-I responses in respiratory as well as reemerging flavivirus infections of public health significance and the molecular mechanisms by which viral proteins antagonize the establishment of an antiviral host defense. Antiviral effects and immune modulation of IFN-stimulated genes is discussed in resisting and controlling pathogens. Understanding the mechanisms of these processes will be crucial in determining how viral replication can be effectively controlled and in developing safe and effective vaccines and novel therapeutic strategies.
Palabras clave:
Respiratory Viruses
,
Re-emerging diseases
,
Interferons Type I
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Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Acosta, Patricio Leandro; Byrne, Alana Brooke; Hijano, Diego Raúl; Talarico, Laura Beatriz; Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections; Hindawi Publishing Corporation; Journal of Immunology Research; 2020; 5-2020; 1-27
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