Artículo
Serum biomarkers for the prediction of hepatocellular carcinoma
Debes, José D.; Romagnoli, Pablo Alberto
; Prieto, Jhon; Arrese, Marco; Mattos, Angelo Z.; Boonstra, André
Fecha de publicación:
04/2021
Editorial:
Multidisciplinary Digital Publishing Institute
Revista:
Cancers
e-ISSN:
2072-6694
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of people with HCC is very low and has been attributed to late diagnosis with limited treatment options. Combining ultrasound and the biomarker alpha-fetoprotein (AFP) is currently one of the most widely used screening combinations for HCC. However, the clinical utility of AFP is controversial, and the frequency and operator-dependence of ultrasound lead to a variable degree of sensitivity and specificity across the globe. In this review, we summarize recent developments in the search for non-invasive serum biomarkers for early detection of HCC to improve prognosis and outcome for patients. We focus on tumor-associated protein markers, immune mediators (cytokines and chemokines), and micro-RNAs in serum or circulating extracellular vesicles and examine their potential for clinical application.
Palabras clave:
BIOMARKER
,
CYTOKINES
,
HEPATOCELLULAR CARCINOMA
,
MICRORNA
,
TUMOR MARKER
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Debes, José D.; Romagnoli, Pablo Alberto; Prieto, Jhon; Arrese, Marco; Mattos, Angelo Z.; et al.; Serum biomarkers for the prediction of hepatocellular carcinoma; Multidisciplinary Digital Publishing Institute; Cancers; 13; 7; 4-2021; 1-13
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