Mostrar el registro sencillo del ítem

dc.contributor.author
Urzúa Pizarro, Natala Francisca  
dc.contributor.author
Messina, María Jimena  
dc.contributor.author
Prieto, Guillermo Fermín  
dc.contributor.author
Lüders, Carlos  
dc.contributor.author
Errecalde, Carlos  
dc.date.available
2022-09-13T17:31:44Z  
dc.date.issued
2020-04  
dc.identifier.citation
Urzúa Pizarro, Natala Francisca; Messina, María Jimena; Prieto, Guillermo Fermín; Lüders, Carlos; Errecalde, Carlos; Pharmacokinetics and tissue disposition of enrofloxacin in rainbow trout after different routes of administration; Taylor & Francis Ltd; Xenobiotica; 50; 10; 4-2020; 1236-1241  
dc.identifier.issn
0049-8254  
dc.identifier.uri
http://hdl.handle.net/11336/168572  
dc.description.abstract
Plasma pharmacokinetics (PK) and tissue disposition of enrofloxacin (EFX) was studied in rainbow trout (Oncorhynchus mykiss) after a single oral administration of 10 mg/kg, and by immersion baths of 20 ppm during 2.5 h and 100 ppm during 0.5 h, at water temperature of 16.3 ± 0.3 °C. Concentrations of EFX in plasma and tissues (skin, muscle, liver, kidney and gut) were determined using high performance liquid chromatography (HPLC) with fluorescence detection. Pharmacokinetic parameters were analyzed with a non-compartmental model. After oral administration, t½β, AUC and AUCtissues/AUCplasma ratio were 42.98 h, 21.80μg-h/ml and ≤ 18.63, respectively. After immersion baths of 20 ppm during 2.5 h and 100 ppm during 0.5 h, the t½β, AUC and AUCtissues/AUCplasma were 42.77 and 44.67, 9.83 and 12.83 μg-h/ml and ≤ 9.81 and ≤ 7.13, respectively. Therefore, oral (10 mg/kg) and bath administration in rainbow trout can provide AUC/MIC of ≥125 and Cmax/MIC of ≥10 to treat diseases caused by susceptible bacteria with MIC ≤ 0.04 μg/ml. This information can be helpful for the right use of EFX in rainbow trout. Also, this is the first study that determines the antibiotic tissue disposition in rainbow trout by using different administration routes.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis Ltd  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BATH  
dc.subject
ENROFLOXACIN  
dc.subject
ORAL  
dc.subject
PLASMA KINETICS  
dc.subject
RAINBOW TROUT  
dc.subject
TISSUES DISPOSITION  
dc.subject
WITHDRAWAL PERIOD  
dc.subject.classification
Otras Ciencias Veterinarias  
dc.subject.classification
Ciencias Veterinarias  
dc.subject.classification
CIENCIAS AGRÍCOLAS  
dc.title
Pharmacokinetics and tissue disposition of enrofloxacin in rainbow trout after different routes of administration  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-09-13T16:26:29Z  
dc.journal.volume
50  
dc.journal.number
10  
dc.journal.pagination
1236-1241  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Urzúa Pizarro, Natala Francisca. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Clinica Animal. Área de Cirugía Experimental.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Messina, María Jimena. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina  
dc.description.fil
Fil: Prieto, Guillermo Fermín. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina  
dc.description.fil
Fil: Lüders, Carlos. Universidad Católica de Temuco; Chile  
dc.description.fil
Fil: Errecalde, Carlos. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina  
dc.journal.title
Xenobiotica  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/00498254.2020.1747119  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/00498254.2020.1747119