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dc.contributor.author
Miksztowicz, Veronica Julieta
dc.contributor.author
Schreier, Laura Ester
dc.contributor.author
McCoy, Mary
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Lucero, Diego Martín
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Fassio, Eduardo
dc.contributor.author
Billheimer, Jeffrey
dc.contributor.author
Rader, Daniel J.
dc.contributor.author
Berg, Gabriela Alicia
dc.date.available
2017-05-22T22:13:08Z
dc.date.issued
2014-03
dc.identifier.citation
Miksztowicz, Veronica Julieta; Schreier, Laura Ester; McCoy, Mary; Lucero, Diego Martín; Fassio, Eduardo; et al.; Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity; American Heart Association; Arteriosclerosis Thrombosis And Vascular Biology; 34; 3; 3-2014; 669-675
dc.identifier.issn
1079-5642
dc.identifier.uri
http://hdl.handle.net/11336/16847
dc.description.abstract
Objective—To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride (TG)-hydrolyses to complete the analyses of SN1 lipolytic enzymes in the same patient. Approach and Results—Plasma EL, HL, and LPL activities were evaluated in 59 patients with MS and 36 controls. A trend toward higher EL activity was observed in MS. EL activity was increased in obese compared with normal weight group (P=0.009) and was negatively associated with high-density lipoprotein–cholesterol (P=0.014 and P=0.005) and apolipoprotein A-I (P=0.045 and P=0.001) in control and MS group, respectively. HL activity, as TG-hydrolase, was increased in MS (P=0.025) as well as in obese group (P=0.017); directly correlated with low-density lipoprotein–cholesterol (P=0.005) and apolipoprotein B (P=0.003) and negatively with high-density lipoprotein–cholesterol (P=0.021) in control group. LPL was decreased in MS (P<0.001) as well as in overweight and obese compared with normal weight group (P=0.015 and P=0.004, respectively); inversely correlated %TG-very low-density lipoproteins (P=0.04) and TG/apolipoprotein B index (P=0.013) in control group. These associations were not found in MS. Conclusions—We describe for the first time EL and HL activity as phospholipases in MS/obesity, being both responsible for high-density lipoprotein catabolism. Our results elucidate part of the remaining controversies about SN1 lipases activity in MS and different grades of obesity. The impact of insulin resistance on the activity of the 3 enzymes determines the lipoprotein alterations observed in these states.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Heart Association
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lipg Protein
dc.subject
Hepatic Lipase
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Human
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Lipoprotein Lipase
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Metabolic Syndrome X
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Obesity
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Phospholipases
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Otras Ciencias de la Salud
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Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-19T18:12:37Z
dc.identifier.eissn
1524-4636
dc.journal.volume
34
dc.journal.number
3
dc.journal.pagination
669-675
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Filadelfia
dc.description.fil
Fil: Miksztowicz, Veronica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: McCoy, Mary. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Lucero, Diego Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Fassio, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital "Prof. Alejandro Posadas"; Argentina
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Fil: Billheimer, Jeffrey. University of Pennsylvania; Estados Unidos
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Fil: Rader, Daniel J.. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Arteriosclerosis Thrombosis And Vascular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1161/ATVBAHA.113.303027
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://atvb.ahajournals.org/content/34/3/669


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