Artículo
Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
Abascal, Estefanía; Herranz, Marta; Acosta, Fermín Eloy; Agapito, Juan; Cabibbe, Andrea M.; Monteserin, Johana
; Ruiz Serrano, María Jesús; Gijón, Paloma; Fernández González, Francisco; Lozano, Nuria; Chiner Oms, Álvaro; Cáceres, Tatiana; Pintado, Pilar Gómez; Acín, Enrique; Valencia, Eddy; Muñoz, Patricia; Comas, Iñaki; Cirillo, Daniela M.; Ritacco, Gloria Viviana
; Gotuzzo, Eduardo; García de Viedma, Darío
Fecha de publicación:
12/2020
Editorial:
Nature Research
Revista:
Scientific Reports
e-ISSN:
2045-2322
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
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Citación
Abascal, Estefanía; Herranz, Marta; Acosta, Fermín Eloy; Agapito, Juan; Cabibbe, Andrea M.; et al.; Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-8
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