Artículo
Revenant: A database of resurrected proteins
Carletti, Matías Sebastian
; Monzon, Alexander
; Garcia Rios, Emilio; Benítez, Guillermo Ignacio
; Hirsh, Layla; Fornasari, Maria Silvina
; Parisi, Gustavo Daniel
Fecha de publicación:
01/2020
Editorial:
Oxford University Press
Revista:
Database
e-ISSN:
1758-0463
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Revenant is a database of resurrected proteins coming from extinct organisms. Currently, it contains a manually curated collection of 84 resurrected proteins derived from bibliographic data. Each protein is extensively annotated, including structural, biochemical and biophysical information. Revenant contains a browse capability designed as a timeline from where the different proteins can be accessed. The oldest Revenant entries are between 4200 and 3500 million years ago, while the younger entries are between 8.8 and 6.3 million years ago. These proteins have been resurrected using computational tools called ancestral sequence reconstruction techniques combined with wet-laboratory synthesis and expression. Resurrected proteins are commonly used, with a noticeable increase during the past years, to explore and test different evolutionary hypotheses such as protein stability, to explore the origin of new functions, to get biochemical insights into past metabolisms and to explore specificity and promiscuous behaviour of ancient proteins.
Palabras clave:
Reconstruction
,
Ancestral
,
PROTEIN evolution
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Carletti, Matías Sebastian; Monzon, Alexander; Garcia Rios, Emilio; Benítez, Guillermo Ignacio; Hirsh, Layla; et al.; Revenant: A database of resurrected proteins; Oxford University Press; Database; 2020; baaa031; 1-2020; 1-7
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