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Artículo

Metalloproteomics analysis in human mammary cell lines treated with inorganic mercury

Ávila Maniero, MariángelesIcon ; Wuilloud, Rodolfo GermanIcon ; Callegari, Eduardo Alberto; Smichowski, Patricia NoraIcon ; Fanelli, Mariel AndreaIcon
Fecha de publicación: 03/2020
Editorial: Elsevier Gmbh
Revista: Journal of Trace Elements in Medicine and Biology
ISSN: 0946-672X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Químicas

Resumen

The interest in inorganic Hg toxicity and carcinogenicity has been pointed to target organs such as kidney, brain or placenta, but only a few studies have focused on the mammary gland. In this work, analytical combination techniques (SDS-PAGE followed by CV-AFS, and nanoUPLC-ESI-MS/MS) were used to determine proteins that could bind Hg in three human mammary cell lines. Two of them were tumorigenic (MCF-7 and MDA-MB-231) and the other one was the non-tumorigenic cell line (MCF-10A). There are no studies that provide this kind of information in breast cell lines with IHg treatment. Previously, we described the viability, uptake and the subcellular distribution of Hg in human breast cells and analysis of RNA-seq about the genes that encode proteins which are related to cytotoxicity of Hg. This work provides important protein candidates for further studies of Hg toxicity in the mammary gland, thus expanding our understanding of how environmental contaminants might affect tumor progression and contribute with future therapeutic methods.
Palabras clave: MAMMARY HUMAN CELLS LINES , MERCURY , METALLOMICS , TOXICITY
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/168204
DOI: http://dx.doi.org/10.1016/j.jtemb.2019.126441
URL: https://www.sciencedirect.com/science/article/abs/pii/S0946672X19302792
Colecciones
Articulos(ICB)
Articulos de INSTITUTO INTERDISCIPLINARIO DE CIENCIAS BASICAS
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Ávila Maniero, Mariángeles; Wuilloud, Rodolfo German; Callegari, Eduardo Alberto; Smichowski, Patricia Nora; Fanelli, Mariel Andrea; Metalloproteomics analysis in human mammary cell lines treated with inorganic mercury; Elsevier Gmbh; Journal of Trace Elements in Medicine and Biology; 58; 3-2020
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