Mostrar el registro sencillo del ítem
dc.contributor.author
Rey, Rodolfo Alberto
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2022-09-08T18:55:33Z
dc.date.issued
2021-10
dc.identifier.citation
Rey, Rodolfo Alberto; Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release; Endocrine Society; Endocrinology; 162; 10; 10-2021; 1-2
dc.identifier.issn
0013-7227
dc.identifier.uri
http://hdl.handle.net/11336/168050
dc.description.abstract
The mammalian testis is formed by 2 morphologically and functionally distinct compartments: the seminiferous tubules and the interstitial tissue. The seminiferous tubules contain the germ cell population, originating the male gametes in the adult, and the somatic Sertoli cell lineage. In the interstitial tissue lies the Leydig cell population, responsible for androgen secretion, amid connective tissue with blood vessels and nerves. The structure and function of the testes show remarkable changes during postnatal life, especially during pubertal maturation, driven by androgens. One notorious transformation occurs within the seminiferous tubules: prepubertal spermatogenesis, limited to spermatogonial mitoses, switches to adult spermatogenesis, where spermatogonial proliferation is followed by 2 successive meiotic divisions and spermatid maturation leading to the production and release of spermatozoa. This gonad-specific biologic process depends essentially on the support given by mature Sertoli cells. While molecules coming from the blood vessels present in the interstitial tissue have free access to spermatogonia, meiotic and postmeiotic germ cells are completely isolated from blood-borne substances. This is mainly due to the development of the blood-testis barrier (BTB) during pubertal maturation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Endocrine Society
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ACTIN
dc.subject
APICAL ECTOPLASMIC SPECIALIZATIONS
dc.subject
ARP3
dc.subject
EPS8
dc.subject
MTORC1
dc.subject
MTORC2
dc.subject
ROR2
dc.subject.classification
Bioquímica y Biología Molecular
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Básica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-23T20:52:48Z
dc.journal.volume
162
dc.journal.number
10
dc.journal.pagination
1-2
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Washington D.C
dc.description.fil
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
dc.journal.title
Endocrinology
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/doi/10.1210/endocr/bqab159/6342110
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/endocr/bqab159
Archivos asociados