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Artículo

Impact of infection dose and previous serum antibodies against the Locus of Enterocyte effacement proteins on Escherichia Coli O157:H7 shedding in calves following experimental infection

Martorelli, LuisinaIcon ; Hovde, C. J.; Vilte, D. A.; Albanese, A.; Zotta, E.; Ibarra, Cristina AdrianaIcon ; Cantet, Rodolfo Juan CarlosIcon ; Mercado, E. C.; Cataldi, Angel AdrianIcon
Fecha de publicación: 2015
Editorial: Hindawi Publishing Corporation
Revista: BioMed Research International
ISSN: 2314-6133
e-ISSN: 2314-6141
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biotecnología relacionada con la Salud

Resumen

Escherichia coli O157:H7 is the main causative agent of haemolytic uremic syndrome. Cattle are the main reservoir of these bacteria, and have been shown to develop immune response to colonization. Our aim was to investigate the faecal shedding pattern of E. coli O157:H7 in calves challenged intragastrically with either 108 or 1010 CFU, as well as the ability of specific preexisting antibodies to reduce shedding of the pathogen. Shedding was analysed by direct counting as well as enrichment of rectoanal mucosal swabs. Statistical analysis was performed using a linear model for repeated measures with and without the inclusion of preexisting antibodies against the carboxy-terminal fraction of intimin- (-intimin C280) as a covariable. Results suggest that there is a statistical difference in the area under the shedding curves between both doses for 14 as well as 28 days after challenge (p = 0.0069 and 0.0209, resp.). This difference is increased when the prechallenge antibodies are taken into account (p = 0.0056 and 0.0185). We concluded that the bacterial dose influences shedding on calves experimentally challenged and that preexisting antibodies against E. coli O157:H7 -intimin C280 could partially reduce faecal excretion.
Palabras clave: E. Coli O157:H7 , Calves , Experimental Infection , Antibodies Anti-Lee
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/16763
DOI: http://dx.doi.org/10.1155/2015/290679
URL: https://www.hindawi.com/journals/bmri/2015/290679/
Colecciones
Articulos(OCA PQUE. CENTENARIO)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA PQUE. CENTENARIO
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Martorelli, Luisina; Hovde, C. J.; Vilte, D. A.; Albanese, A.; Zotta, E.; et al.; Impact of infection dose and previous serum antibodies against the Locus of Enterocyte effacement proteins on Escherichia Coli O157:H7 shedding in calves following experimental infection; Hindawi Publishing Corporation; BioMed Research International; 2015; -1-2015; 1-8; 290679
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