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dc.contributor.author
Masson, Walter
dc.contributor.author
Lavalle Cobo, Augusto
dc.contributor.author
Nogueira, Juan Patricio
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dc.date.available
2022-09-06T10:33:06Z
dc.date.issued
2021-08
dc.identifier.citation
Masson, Walter; Lavalle Cobo, Augusto; Nogueira, Juan Patricio; Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis; MDPI; Cells; 10; 8; 8-2021; 1-10
dc.identifier.issn
2073-4409
dc.identifier.uri
http://hdl.handle.net/11336/167457
dc.description.abstract
(1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with T2D. (2) We performed a systematic review and meta-analysis of SGLT2-i therapy on T2D patients, reporting data on changes in EAT after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases. A random effects or fixed effects model meta-analysis was then applied. (3) Results: A total of three studies (n = 64 patients with SGLT2-i, n = 62 with standard therapy) were included in the final analysis. SGLT2 inhibitors reduced EAT (SMD: −0.82 (−1.49; −0.15); p < 0.0001). An exploratory analysis showed that HbA1c was significantly reduced with SGLT2-i use, while body mass index was not significantly reduced with this drug. (4) Conclusions: This meta-analysis suggests that the amount of EAT is significantly reduced in T2D patients with SGLT2-i treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
EPICARDIAL ADIPOSE TISSUE
dc.subject
META-ANALYSIS
dc.subject
SODIUM–GLUCOSE CO-TRANSPORTER-2 INHIBITORS
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-16T20:37:18Z
dc.journal.volume
10
dc.journal.number
8
dc.journal.pagination
1-10
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.description.fil
Fil: Masson, Walter. No especifíca;
dc.description.fil
Fil: Lavalle Cobo, Augusto. No especifíca;
dc.description.fil
Fil: Nogueira, Juan Patricio. Universidad Nacional de Formosa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
dc.journal.title
Cells
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/cells10082150
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