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dc.contributor.author
D'Aeth, Joshua C.
dc.contributor.author
van der Linden, Mark P. G.
dc.contributor.author
McGee, Lesley
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dc.contributor.author
de Lencastre, Herminia
dc.contributor.author
Turner, Paul
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Song, Jae Hoon
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Lo, Stephanie W.
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Gladstone, Rebecca A.
dc.contributor.author
Sá Leão, Raquel
dc.contributor.author
Ko, Kwan Soo
dc.contributor.author
Hanage, William P.
dc.contributor.author
Breiman, Robert F.
dc.contributor.author
Beall, Bernard
dc.contributor.author
Bentley, Stephen D.
dc.contributor.author
Croucher, Nicholas J.
dc.contributor.author
Faccone, Diego Francisco
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dc.contributor.author
The GPS Consortium
dc.date.available
2022-09-05T18:18:44Z
dc.date.issued
2021-07-14
dc.identifier.citation
D'Aeth, Joshua C.; van der Linden, Mark P. G.; McGee, Lesley; de Lencastre, Herminia; Turner, Paul; et al.; The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci; eLife Sciences Publications Ltd; eLife; 10; 14-7-2021; 1-35
dc.identifier.issn
2050-084X
dc.identifier.uri
http://hdl.handle.net/11336/167401
dc.description.abstract
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
eLife Sciences Publications Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
STREPTOCOCCUS PNEUMONIAE
dc.subject
ANTIBIOTIC
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RECOMBINATION
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EVOLUTION
dc.subject.classification
Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-16T18:06:07Z
dc.identifier.eissn
2050-084X
dc.journal.volume
10
dc.journal.pagination
1-35
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Cambridge
dc.description.fil
Fil: D'Aeth, Joshua C.. Imperial College London; Reino Unido
dc.description.fil
Fil: van der Linden, Mark P. G.. Uniklinik RWTH Aachen; Alemania
dc.description.fil
Fil: McGee, Lesley. Centers for Disease Control and Prevention; Estados Unidos
dc.description.fil
Fil: de Lencastre, Herminia. Universidade Nova de Lisboa; Portugal. The Rockefeller University; Estados Unidos
dc.description.fil
Fil: Turner, Paul. Angkor Hospital for Children; Camboya. University of Oxford; Reino Unido
dc.description.fil
Fil: Song, Jae Hoon. Sungkyunkwan University School of Medicine; Corea del Sur
dc.description.fil
Fil: Lo, Stephanie W.. Wellcome Genome Campus; Reino Unido
dc.description.fil
Fil: Gladstone, Rebecca A.. Wellcome Genome Campus; Reino Unido
dc.description.fil
Fil: Sá Leão, Raquel. Universidade Nova de Lisboa; Portugal
dc.description.fil
Fil: Ko, Kwan Soo. Sungkyunkwan University School of Medicine; Corea del Sur
dc.description.fil
Fil: Hanage, William P.. Harvard University. Harvard School of Public Health; Estados Unidos
dc.description.fil
Fil: Breiman, Robert F.. University of Emory; Estados Unidos
dc.description.fil
Fil: Beall, Bernard. Centers for Disease Control and Prevention; Estados Unidos
dc.description.fil
Fil: Bentley, Stephen D.. Wellcome Genome Campus; Reino Unido
dc.description.fil
Fil: Croucher, Nicholas J.. Imperial College London; Reino Unido
dc.description.fil
Fil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: The GPS Consortium. The GPS Consortium; Estados Unidos
dc.journal.title
eLife
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/67113
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7554/eLife.67113
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