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dc.contributor.author
Benedini, Luciano Alejandro
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Moglie, Yanina Fernanda
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Ruso, Juan Manuel
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Nardi, Sofía
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Messina, Paula Verónica
dc.date.available
2022-09-01T17:48:58Z
dc.date.issued
2021-03
dc.identifier.citation
Benedini, Luciano Alejandro; Moglie, Yanina Fernanda; Ruso, Juan Manuel; Nardi, Sofía; Messina, Paula Verónica; Hydroxyapatite Nanoparticle Mesogens: Morphogenesis of pH-Sensitive Macromolecular Liquid Crystals; American Chemical Society; Crystal Growth & Design; 21; 4; 3-2021; 1-13
dc.identifier.issn
1528-7483
dc.identifier.uri
http://hdl.handle.net/11336/167241
dc.description.abstract
Numerous living structural materials display self-assembly of building blocks. Biological molecular networks exhibit lyotropic liquid crystalline properties that can support non-equilibrium pathways influenced by dynamic processes at the microscale. With the aim of taking a further step toward the conquest of a biomimetic material to apply in calcified tissue regeneration, in this work, we have evaluated the chemical grafting of phosphorous amide (C−N−P) and α-amino phosphonate (N−C−P) molecular fragments on previously created biomimetic hydroxyapatite (HA) nanoparticles (nano-HA). Molecular combinations were selected due to their recognized capability of influencing bone physiology and pathology. We have assessed the effect of the type and degree of nano-HA substitution over the spontaneous self-association of acidic macromolecules that respond to pH stimulation. The produced materials were inspected by Fourier transform infrared and solid-state nuclear magnetic resonance spectroscopy, smallangle X-ray scattering, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and polarized light and high-resolution electron transmission microscopy. A complete analysis of the experimental data proved that under specific synthetic conditions, it is possible to obtain substituted-HA nanoparticles that are able to act as mesogenic agents. These systems that dynamically respond to pH can be tailored in vitro to induce, at concentration values analogous to biogenic ones, lyotropic liquid crystal organization on acid macromolecules.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HYDROXYAPATITE
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ALFA AMINOPHSPHONATES
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LIQUID CRYSTAL
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BONE TISSUE
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Química Coloidal
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Hydroxyapatite Nanoparticle Mesogens: Morphogenesis of pH-Sensitive Macromolecular Liquid Crystals
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-21T18:03:39Z
dc.journal.volume
21
dc.journal.number
4
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Benedini, Luciano Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Moglie, Yanina Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Ruso, Juan Manuel. Universidad de Santiago de Compostela. Facultad de Física; España
dc.description.fil
Fil: Nardi, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Messina, Paula Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.journal.title
Crystal Growth & Design
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.cgd.0c01582
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acs.cgd.0c01582
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