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dc.contributor.author
Kim, Hyun Seok
dc.contributor.author
Kim, Hyun Seok
dc.contributor.author
Sookoian, Silvia Cristina
dc.contributor.author
Sookoian, Silvia Cristina
dc.contributor.author
Hernaez, Ruben
dc.contributor.author
Hernaez, Ruben
dc.date.available
2022-09-01T12:57:16Z
dc.date.issued
2021-12
dc.date.issued
2021-12
dc.identifier.citation
Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533
dc.identifier.citation
Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533
dc.identifier.issn
0270-9139
dc.identifier.issn
0270-9139
dc.identifier.uri
http://hdl.handle.net/11336/167133
dc.description.abstract
Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.
dc.description.abstract
Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.
dc.format
application/pdf
dc.format
application/pdf
dc.language.iso
eng
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc.
dc.publisher
John Wiley & Sons Inc.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GWAS
dc.subject
GWAS
dc.subject
GENETICS
dc.subject
GENETICS
dc.subject
NASH
dc.subject
NASH
dc.subject
NAFLD
dc.subject
NAFLD
dc.subject.classification
Gastroenterología y Hepatología
dc.subject.classification
Gastroenterología y Hepatología
dc.subject.classification
Medicina Clínica
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
dc.title
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-25T12:40:18Z
dc.journal.volume
74
dc.journal.volume
74
dc.journal.number
6
dc.journal.number
6
dc.journal.pagination
3529-3533
dc.journal.pagination
3529-3533
dc.journal.pais
Estados Unidos
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos
dc.description.fil
Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos
dc.description.fil
Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos
dc.journal.title
Hepatology (Baltimore, Md.)
dc.journal.title
Hepatology (Baltimore, Md.)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/hep.32175
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/hep.32175
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