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Artículo

Circulating and adipose tissue matrix metalloproteinases in cardiometabolic risk environments: pathophysiological aspects

Berg, Gabriela AliciaIcon ; Schreier, Laura Ester; Miksztowicz, Veronica JulietaIcon
Fecha de publicación: 02/2014
Editorial: De Gruyter
Revista: Hormone Molecular Biology and Clinical Investigation
ISSN: 1868-1883
e-ISSN: 1868-1891
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

Matrix metalloproteinases (MMPs) play an important role during physiological tissue remodeling in embryonic development and angiogenesis, as well as in pathophysiological conditions such as obesity and development and vulnerability of atherosclerotic plaque. Moreover, MMP circulating levels have emerged as potential biomarkers of cardiovascular disease. MMP expression and activity are regulated by different factors such as insulin resistance and obesity. Expanded fat tissue has been demonstrated to be an active organ, where MMPs also exert a role in adipogenesis, angiogenesis, and proliferation of extracellular matrix (ECM). However, the lack of association between adipose tissue and plasma levels of some MMPs, specifically MMP-2 and MMP-9, suggests that this tissue is not a major contributor to circulating gelatinases. MMPs are also co-expressed or co-repressed in response to inflammatory adipocytokines, like adiponectin and leptin. Adiponectin may also play a protective role in plaque rupture through selectively increasing the tissue inhibitor of metalloproteinase (TIMP) expression. Leptin induces the expression of MMP-2 activators as well as the expression of MMP-2, MMP-9, and TIMP-1 in different human cells. Furthermore, sex hormones also participate in MMP regulation. In postmenopausal women, hormone replacement therapy produces an increase in MMP activity, leading to a breakdown in ECM homeostasis and accelerated progression of vascular pathologies. Besides, in men, an inverse relationship between testosterone levels and MMP-2 activity has been described. It is still necessary to go forward in the study of MMPs in different metabolic situations to corroborate their role as vulnerable plaque biomarkers.
Palabras clave: Adipose Tissue , Insulin Resistance , Matrix Metalloproteinases , Sex Hormones
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/16681
URL: https://www.degruyter.com/view/j/hmbci.2014.17.issue-2/hmbci-2013-0069/hmbci-201
DOI: http://dx.doi.org/10.1515/hmbci-2013-0069
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Berg, Gabriela Alicia; Schreier, Laura Ester; Miksztowicz, Veronica Julieta; Circulating and adipose tissue matrix metalloproteinases in cardiometabolic risk environments: pathophysiological aspects; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 17; 2; 2-2014; 79-87
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