Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Interoception primes emotional processing: multimodal evidence from neurodegeneration

Salamone, Paula CelesteIcon ; Legaz, AgustinaIcon ; Sedeño, LucasIcon ; Moguilner, Sebastian Gabriel; Fraile Vázquez, Matías; Gonzalez Campo, CeciliaIcon ; Fittipaldi, María SolIcon ; Yoris, Adrián IsidroIcon ; Miranda, MagdalenaIcon ; Birba, AgustinaIcon ; Galiani, Agustina; Abrevaya, SofiaIcon ; Neely, Alejandra; Martorell Caro, Miguel AngelIcon ; Alifano Ferrero, FlorenciaIcon ; Villagra, Roque; Anunziata, FlorenciaIcon ; Oliveira, Maira Okada de; Pautassi, Ricardo MarcosIcon ; Slachevsky, Andrea; Serrano, Cecilia Mariela; García, Adolfo MartínIcon ; Ibáñez, Santiago AgustínIcon
Fecha de publicación: 05/2021
Editorial: Society for Neuroscience
Revista: Journal of Neuroscience
ISSN: 0270-6474
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Psicología

Resumen

Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive and control-exteroceptive priming conditions followed by post-interoception and post-exteroception facial emotion recognition (FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease (PD), and Alzheimer's disease (AD). We measured online EEG modulations of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity patterns. Behaviorally, post-interoception negative FER was enhanced in HCs but selectively disrupted in bvFTD and PD, with AD presenting generalized disruptions across emotion types. Only bvFTD presented impaired interoceptive accuracy. Increased HEP modulations during post-interoception negative FER was observed in HCs and AD, but not in bvFTD or PD patients. Across all groups, post-interoception negative FER correlated with the volume of the insula and the ACC. Also, negative FER was associated with functional connectivity along the (a) salience network in the post-interoception condition, and along the (b) executive network in the post-exteroception condition. These patterns were selectively disrupted in bvFTD (a) and PD (b), respectively. Our approach underscores the multidimensional impact of interoception on emotion, while revealing a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the fields of nteroception, emotion, allostasis, and neurodegeneration.
Palabras clave: ALZHEIMER'S DISEASE , BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA , EMOTION , INTEROCEPTION , PARKINSON'S DISEASE , PRIMING
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 2.217Mb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/166574
URL: https://www.jneurosci.org/content/41/19/4276?fbclid=IwAR34ckA15T_gWhpb1mVm4XjlIy
DOI: https://doi.org/10.1523/JNEUROSCI.2578-20.2021
Colecciones
Articulos(INCYT)
Articulos de INSTITUTO DE NEUROCIENCIAS COGNITIVAS Y TRASLACIONAL
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Salamone, Paula Celeste; Legaz, Agustina; Sedeño, Lucas; Moguilner, Sebastian Gabriel; Fraile Vázquez, Matías; et al.; Interoception primes emotional processing: multimodal evidence from neurodegeneration; Society for Neuroscience; Journal of Neuroscience; 41; 19; 5-2021; 4276-4292
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES