Mostrar el registro sencillo del ítem
dc.contributor.author
Jiang, Shuai
dc.contributor.author
Da Silva, Lucas Caire
dc.contributor.author
Ivanov, Tsvetomir
dc.contributor.author
Mottola, Milagro
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Landfester, Katharina
dc.date.available
2022-08-25T14:06:39Z
dc.date.issued
2022-02
dc.identifier.citation
Jiang, Shuai; Da Silva, Lucas Caire; Ivanov, Tsvetomir; Mottola, Milagro; Landfester, Katharina; Synthetic silica nano-organelles for regulation of cascade reactions in multi-compartmentalized systems; Wiley VCH Verlag; Angewandte Chemie; 61; 6; 2-2022; 1-6
dc.identifier.issn
1433-7851
dc.identifier.uri
http://hdl.handle.net/11336/166571
dc.description.abstract
In eukaryotic cells, enzymes are compartmentalized into specific organelles so that different reactions and processes can be performed efficiently and with a high degree of control. In this work, we show that these features can be artificially emulated in robust synthetic organelles constructed using an enzyme co-compartmentalization strategy. We describe an in situ encapsulation approach that allows enzymes to be loaded into silica nanoreactors in well-defined compositions. The nanoreactors can be combined into integrated systems to produce a desired reaction outcome. We used the selective enzyme co-compartmentalization and nanoreactor integration to regulate competitive cascade reactions and to modulate the kinetics of sequential reactions involving multiple nanoreactors. Furthermore, we show that the nanoreactors can be efficiently loaded into giant polymer vesicles, resulting in multi-compartmentalized microreactors.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
SYNTHETIC CELLS
dc.subject
CASCADE REACTIONS
dc.subject
ENZYMATIC REACTIONS
dc.subject
NANOREACTORS
dc.subject
NANOORGANELLES
dc.subject.classification
Biofísica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Synthetic silica nano-organelles for regulation of cascade reactions in multi-compartmentalized systems
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-23T11:14:38Z
dc.journal.volume
61
dc.journal.number
6
dc.journal.pagination
1-6
dc.journal.pais
Alemania
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Jiang, Shuai. Max Planck Institute for Polymer Research; Alemania. Ocean University of China; China
dc.description.fil
Fil: Da Silva, Lucas Caire. Max Planck Institute for Polymer Research; Alemania
dc.description.fil
Fil: Ivanov, Tsvetomir. Max Planck Institute for Polymer Research; Alemania
dc.description.fil
Fil: Mottola, Milagro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
dc.description.fil
Fil: Landfester, Katharina. Max Planck Institute for Polymer Research; Alemania
dc.journal.title
Angewandte Chemie
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/anie.202113784
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/anie.202113784
Archivos asociados