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dc.contributor.author
Guillard, Amandine Marie  
dc.contributor.author
Battista, Petronilla  
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García, Adolfo Martín  
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Allen, Isabel E.  
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Miller, Zachary A.  
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Gorno Tempini, María Luisa  
dc.contributor.author
Montembeault, Maxime  
dc.date.available
2022-08-24T19:21:53Z  
dc.date.issued
2021-12  
dc.identifier.citation
Guillard, Amandine Marie; Battista, Petronilla; García, Adolfo Martín; Allen, Isabel E.; Miller, Zachary A.; et al.; Speech and language impairments in behavioral variant frontotemporal dementia: a systematic review; Elsevier; Neuroscience and Biobehavioral Reviews; 131; 12-2021; 1076-1095  
dc.identifier.issn
0149-7634  
dc.identifier.uri
http://hdl.handle.net/11336/166490  
dc.description.abstract
Although behavioral variant frontotemporal dementia (bvFTD) is classically defined by behavioral and socio-emotional changes, impairments often extend to other cognitive functions. These include early speech and language deficits related to the disease's core neural disruptions. Yet, their scope and clinical relevance remains poorly understood. This systematic review characterizes such disturbances in bvFTD, considering clinically, neuroanatomically, genetically, and neuropathologically defined subgroups. We included 181 experimental studies, with at least 5 bvFTD patients diagnosed using accepted criteria, comparing speech and language outcomes between bvFTD patients and healthy controls or between bvFTD subgroups. Results reveal extensive and heterogeneous deficits across cohorts, with (a) consistent lexico-semantic, reading & writing, and prosodic impairments; (b) inconsistent deficits in motor speech and grammar; and (c) relative preservation of phonological skills. Also, preliminary findings suggest that the severity of speech and language deficits might be associated with global cognitive impairment, predominantly temporal or fronto-temporal atrophy and MAPT mutations (vs C9orf72). Although under-recognized, these impairments contribute to patient characterization and phenotyping, while potentially informing diagnosis and management.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA  
dc.subject
GRAMMAR  
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LANGUAGE  
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LEXICO-SEMANTICS  
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PHONOLOGY  
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PROSODY  
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READING  
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SPEECH  
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SYSTEMATIC REVIEW  
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WRITING  
dc.subject.classification
Lingüística  
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Lengua y Literatura  
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HUMANIDADES  
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Psicología  
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Psicología  
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CIENCIAS SOCIALES  
dc.title
Speech and language impairments in behavioral variant frontotemporal dementia: a systematic review  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-08-19T14:47:53Z  
dc.journal.volume
131  
dc.journal.pagination
1076-1095  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Guillard, Amandine Marie. University of California; Estados Unidos. Toulouse University Hospital; Francia  
dc.description.fil
Fil: Battista, Petronilla. University of California; Estados Unidos. Istituti Clinici Scientifici Maugeri; Italia  
dc.description.fil
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of California; Estados Unidos. Universidad de San Andrés; Argentina. Universidad de Santiago de Chile; Chile  
dc.description.fil
Fil: Allen, Isabel E.. University of California; Estados Unidos  
dc.description.fil
Fil: Miller, Zachary A.. University of California; Estados Unidos  
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Fil: Gorno Tempini, María Luisa. University of California; Estados Unidos  
dc.description.fil
Fil: Montembeault, Maxime. University of California; Estados Unidos  
dc.journal.title
Neuroscience and Biobehavioral Reviews  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0149763421004577  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.neubiorev.2021.10.015