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Artículo

Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes

Bobillo, Maria CeciliaIcon ; Navoni, Julio A.; Olmos, Valentina; Merini, Luciano JoseIcon ; Villaamil Lepori, Edda; Corach, DanielIcon
Fecha de publicación: 01/2014
Editorial: e-Century Publishing
Revista: International Journal of Molecular Epidemiology and Genetics
ISSN: 1948-1756
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Because the ratio between the two major arsenic metabolites is related to the adverse health effects of arsenic, numerous studies have been performed to establish a relationship between the ability to metabolically detoxify arsenic and other variables, including exposure level, gender, age and ethnicity. Because ethnicity may play a key role and provide relevant information for heterogeneous populations, we characterized a group of 70 children from rural schools in the Argentinean provinces of Chaco and Santiago del Estero who were exposed to high levels of arsenic. We used genetic markers for maternal, paternal and bi-parental ancestry to achieve this goal. Our results demonstrate that the Amerindian maternal linages are present in 100% of the samples, whereas the Amerindian component transmitted through the paternal line is less than 10%. Informative markers for autosomal ancestry show a predominantly European ancestry, in which 37% of the samples contained between 90 and 99% European ancestry. The native American component ranged from 50 to 80% in 15.7% of the samples, and in all but four samples, the African component was less than 10%. Correlation analysis demonstrated that the ethnicity and the ratio of the excreted arsenic metabolites monomethyl arsenic and dimethyl arsenic are not associated, dismissing a relationship between ethnic origin and differential metabolism.
Palabras clave: Arsenic , Children , Ethnic Characterization , Ancestral Informative Markers
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/16645
URL: http://www.ijmeg.org/IJMEG_V5N1.html
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939002/
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Bobillo, Maria Cecilia; Navoni, Julio A.; Olmos, Valentina; Merini, Luciano Jose; Villaamil Lepori, Edda; et al.; Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes; e-Century Publishing; International Journal of Molecular Epidemiology and Genetics; 5; 1; 1-2014; 1-10
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