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dc.contributor.author
Azpiroz, Maria Agustina
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dc.contributor.author
Orguilia, Lucila
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dc.contributor.author
Palacio, Maria Ines
dc.contributor.author
Malpartida, Alejandro Rodolfo
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dc.contributor.author
Mayol, Soledad
dc.contributor.author
Mor, Gil
dc.contributor.author
Gutierrez, Gabriela Lidia
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dc.date.available
2022-08-17T15:23:26Z
dc.date.issued
2021-07
dc.identifier.citation
Azpiroz, Maria Agustina; Orguilia, Lucila; Palacio, Maria Ines; Malpartida, Alejandro Rodolfo; Mayol, Soledad; et al.; Potential biomarkers of infertility associated with microbiome imbalances; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 86; 4; 7-2021; 1-10
dc.identifier.issn
1046-7408
dc.identifier.uri
http://hdl.handle.net/11336/165842
dc.description.abstract
Problem: The aim of this study was to investigate the possible relationship between vaginal/rectal microbiome disbalances and miRNA expression with infertility. Method of study: Observational, exploratory, preliminary study. A total of 287 multiple IVF failure infertile patients were recruited. Twenty fertile women, not IVF failure, were recruited as the control group. Swab samples were collected from the vagina and rectum. Microbial composition by NGS and miRNA expression by real-time PCR of vaginal and rectal samples was measured. Immunometabolic markers from blood (insulin, vitamin D, LDL-cholesterol, ANA, TPO, Tg, and ASCA antibodies) and saliva (sIgA) were analyzed. Result(s): Infertile patients showed a lower bacterial richness and increased Firmicutes/Bacteroidetes ratio at rectal level and an increased Lactobacillus brevis/Lactobacillus iners ratio in vaginal samples regarding the fertile group. In the same rectal swab samples, we found that miR-21-5p, which is associated with tight junction disruption and yeast overgrowth, is upregulated and that miR-155-5p, which is associated with inflammation, is overexpressed in the unexplained infertile group (*p <.05). These deregulated miRNAs were also upregulated in the vaginal samples from the same patients (*p <.05). Conclusion: miRNAs could be potential biomarkers of the inflammatory impact of microbiome disbalances in unexplained infertile women.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AUTOANTIBODIES
dc.subject
INFERTILITY
dc.subject
INTESTINAL PERMEABILITY
dc.subject
MICROBIOTA
dc.subject
MIRNAS
dc.subject.classification
Biotecnología relacionada con la Salud
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dc.subject.classification
Biotecnología de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Potential biomarkers of infertility associated with microbiome imbalances
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-16T18:13:31Z
dc.journal.volume
86
dc.journal.number
4
dc.journal.pagination
1-10
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Azpiroz, Maria Agustina. Microgenesis Co; Argentina. Abm Laboratorios Tandil; Argentina
dc.description.fil
Fil: Orguilia, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Inmunogenesis; Argentina
dc.description.fil
Fil: Palacio, Maria Ines. Abm Laboratorios Tandil; Argentina
dc.description.fil
Fil: Malpartida, Alejandro Rodolfo. Microgenesis Co; Argentina
dc.description.fil
Fil: Mayol, Soledad. Inmunogenesis; Argentina
dc.description.fil
Fil: Mor, Gil. Wayne State University (wayne State University); Estados Unidos
dc.description.fil
Fil: Gutierrez, Gabriela Lidia. Microgenesis Co; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
American Journal of Reproductive Immunology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/aji.13438
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/aji.13438
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