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dc.contributor.author
Ntalli, Nikoletta G.
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Cottiglia, Filippo
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Bueno, Carlos Alberto
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Alche, Laura Edith
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Leonti, Marco
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Vargiu, Simona
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Bifulco, Ersilia
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Menkissoglu Spiroudi, Urania
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Caboni, Pierluigi
dc.date.available
2017-05-17T15:40:13Z
dc.date.issued
2010-08
dc.identifier.citation
Ntalli, Nikoletta G.; Cottiglia, Filippo; Bueno, Carlos Alberto; Alche, Laura Edith; Leonti, Marco; et al.; Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits ; Molecular Diversity Preservation International; Molecules; 15; 9; 8-2010; 5866-5877
dc.identifier.issn
1420-3049
dc.identifier.uri
http://hdl.handle.net/11336/16577
dc.description.abstract
The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β- acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Molecular Diversity Preservation International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Methyl Kulonate
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3-Alfa-Tigloylmelianol
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Melianone
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21-Beta-Acetoxy-Melianone
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Cytotoxicity
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Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-15T21:08:50Z
dc.journal.volume
15
dc.journal.number
9
dc.journal.pagination
5866-5877
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Ntalli, Nikoletta G.. Aristotle University of Thessaloniki; Grecia
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Fil: Cottiglia, Filippo. Università degli studi di Cagliari; Italia
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Fil: Bueno, Carlos Alberto. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Alche, Laura Edith. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Leonti, Marco. Università degli studi di Cagliari; Italia
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Fil: Vargiu, Simona. Università degli Studi di Cagliari; Italia
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Fil: Bifulco, Ersilia. Università degli Studi di Cagliari; Italia
dc.description.fil
Fil: Menkissoglu Spiroudi, Urania. Aristotle University of Thessaloniki; Grecia
dc.description.fil
Fil: Caboni, Pierluigi. Università degli Studi di Cagliari; Italia
dc.journal.title
Molecules
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/molecules15095866
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/15/9/5866
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