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Artículo

Temporary effects of neonatal overfeeding on homeostatic control of food intake involve alterations in POMC promoter methylation in male rats

Schumacher, RocioIcon ; Rossetti, María FlorenciaIcon ; Lazzarino, Gisela PaolaIcon ; Canesini, GuillerminaIcon ; García, Ana PaulaIcon ; Stoker, CoraIcon ; Andreoli, Maria FlorenciaIcon ; Ramos, Jorge GuillermoIcon
Fecha de publicación: 15/02/2021
Editorial: Elsevier Ireland
Revista: Molecular and Cellular Endocrinology
ISSN: 0303-7207
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

A small litter (SL) model was used to determine how neonatal overfeeding affects the homeostatic control of food intake in male rats at weaning and postnatal day (PND) 90. At PND4, litters were reduced to small (4 pups/dam) or normal (10 pups/dam) litters. At weaning, SL rats showed higher body weight and characteristic features of the metabolic syndrome. Gene expression of pro-opiomelanocortin (POMC), cocaine and amphetamine regulated transcript, neuropeptide Y (NPY) and leptin and ghrelin (GHSR) receptors were increased and POMC promoter was hypomethylated in arcuate nucleus, indicating that the early development of obesity may involve the GHSR/NPY system and changes in POMC methylation state. At PND90, body weight, metabolic parameters and gene expression were restored; however, POMC methylation state remained altered. This work provides insight into the effects of neonatal overfeeding, showing the importance of developmental plasticity in restoring early changes in central pathways involved in metabolic programming.
Palabras clave: DNA METHYLATION , HOMEOSTATIC SYSTEM , OVERWEIGHT , POSTNATAL PROGRAMING , SMALL LITTER
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/165581
URL: https://linkinghub.elsevier.com/retrieve/pii/S0303720720304251
DOI: http://dx.doi.org/10.1016/j.mce.2020.111123
Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos(ISAL)
Articulos de INSTITUTO DE SALUD Y AMBIENTE DEL LITORAL
Citación
Schumacher, Rocio; Rossetti, María Florencia; Lazzarino, Gisela Paola; Canesini, Guillermina; García, Ana Paula; et al.; Temporary effects of neonatal overfeeding on homeostatic control of food intake involve alterations in POMC promoter methylation in male rats; Elsevier Ireland; Molecular and Cellular Endocrinology; 522; 15-2-2021; 1-9
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