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dc.contributor.author
Blois, Sandra M.
dc.contributor.author
Prince, Paula Denise
dc.contributor.author
Borowski, Sophia
dc.contributor.author
Galleano, Mónica Liliana
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Barrientos, Gabriela Laura
dc.date.available
2022-08-11T15:45:33Z
dc.date.issued
2021-04
dc.identifier.citation
Blois, Sandra M.; Prince, Paula Denise; Borowski, Sophia; Galleano, Mónica Liliana; Barrientos, Gabriela Laura; Placental glycoredox dysregulation associated with disease progression in an animal model of superimposed preeclampsia; MDPI AG; Cells; 10; 4; 4-2021; 800-817
dc.identifier.issn
2073-4409
dc.identifier.uri
http://hdl.handle.net/11336/165205
dc.description.abstract
Pregnancies carried by women with chronic hypertension are at increased risk of superimposed preeclampsia, but the placental pathways involved in disease progression remain poorly understood. In this study, we used the stroke-prone spontaneously hypertensive rat (SHRSP) model to investigate the placental mechanisms promoting superimposed preeclampsia, with focus on cellular stress and its influence on galectin–glycan circuits. Our analysis revealed that SHRSP placentas are characterized by a sustained activation of the cellular stress response, displaying significantly increased levels of markers of lipid peroxidation (i.e., thiobarbituric acid reactive substances (TBARS)) and protein nitration and defective antioxidant enzyme expression as early as gestation day 14 (which marks disease onset). Further, lectin profiling showed that such redox imbalance was associated with marked alterations of the placental glycocode, including a prominent decrease of core 1 O-glycan expression in trophoblasts and increased decidual levels of sialylation in SHRSP placentas. We also observed significant changes in the expression of galectins 1, 3 and 9 with pregnancy progression, highlighting the important role of the galectin signature as dynamic interpreters of placental microenvironmental challenges. Collectively, our findings uncover a new role for the glycoredox balance in the pathogenesis of superimposed preeclampsia representing a promising target for interventions in hypertensive disorders of pregnancy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI AG
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CHRONIC HYPERTENSION
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GLYCOSYLATION
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OXIDATIVE STRESS
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PLACENTA
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PREECLAMPSIA
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Placental glycoredox dysregulation associated with disease progression in an animal model of superimposed preeclampsia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-11T13:00:10Z
dc.journal.volume
10
dc.journal.number
4
dc.journal.pagination
800-817
dc.journal.pais
Suiza
dc.description.fil
Fil: Blois, Sandra M.. University Medical Center Hamburg-Eppendorf; Alemania
dc.description.fil
Fil: Prince, Paula Denise. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Borowski, Sophia. University Medical Center Hamburg-Eppendorf; Alemania
dc.description.fil
Fil: Galleano, Mónica Liliana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Barrientos, Gabriela Laura. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Cells
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4409/10/4/800
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/cells10040800
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