Artículo
What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
Fecha de publicación:
05/2021
Editorial:
Journal of the Serbian Chemical Society
Revista:
Biochemical Journal
ISSN:
0264-6021
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Epithelial plasticity involved the terminal and transitional stages that occur during epithelial- to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET), both are essential at different stages of early embryonic development that have been coopted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing the latest findings of the cellular and molecular basis of the less characterized process of MET during embryonic development, with special attention to the role of microRNAs. Although we take in consideration the necessity of being cautious when extrapolating the obtained evidence, we propose some commonalities between early embryonic development and cancer progression that can shed light into our current understanding of this complex event and might aid in the design of specific therapeutic approaches.
Palabras clave:
EMT
,
MET
,
Epigenetics
,
microRNAs
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Identificadores
Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Bernardi, Yanel Elina; Strobl Mazulla, Pablo Hernan; What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression; Journal of the Serbian Chemical Society; Biochemical Journal; 478; 9; 5-2021; 1809-1825
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