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dc.contributor.author
Crossley, Nicolas A.
dc.contributor.author
Zugman, Andre
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Reyes Madrigal, Francisco
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Czepielewski, Leticia S.
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Castro, Mariana Nair
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Diaz Zuluaga, Ana M.
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Pineda Zapata, Julian A.
dc.contributor.author
Reckziegel, Ramiro
dc.contributor.author
Gadelha, Ary
dc.contributor.author
Jackowski, Andrea
dc.contributor.author
Noto, Cristiano
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Alliende, Luz M.
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Iruretagoyena, Barbara
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Ossandon, Tomas
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Ramirez Mahaluf, Juan P.
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Castañeda, Carmen P.
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Gonzalez Valderrama, Alfonso
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Nachar, Ruben
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León Ortiz, Pablo
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Undurraga, Juan
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López Jaramillo, Carlos
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Guinjoan, Salvador Martín
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Gama, Clarissa S.
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De La Fuente Sandoval, Camilo
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Bressan, Rodrigo A.
dc.date.available
2022-08-10T15:13:03Z
dc.date.issued
2021-02
dc.identifier.citation
Crossley, Nicolas A.; Zugman, Andre; Reyes Madrigal, Francisco; Czepielewski, Leticia S.; Castro, Mariana Nair; et al.; Structural brain abnormalities in schizophrenia in adverse environments: Examining the effect of poverty and violence in six Latin American cities; Royal College Of Psychiatrists; British Journal Of Psychiatry; 218; 2; 2-2021; 112-118
dc.identifier.issn
0007-1250
dc.identifier.uri
http://hdl.handle.net/11336/164971
dc.description.abstract
Summary Background Social and environmental factors such as poverty or violence modulate the risk and course of schizophrenia. However, how they affect the brain in patients with psychosis remains unclear. Aims We studied how environmental factors are related to brain structure in patients with schizophrenia and controls in Latin America, where these factors are large and unequally distributed. Method This is a multicentre study of magnetic resonance imaging in patients with schizophrenia and controls from six Latin American cities. Total and voxel-level grey matter volumes, and their relationship with neighbourhood characteristics such as average income and homicide rates, were analysed with a general linear model. Results A total of 334 patients with schizophrenia and 262 controls were included. Income was differentially related to total grey matter volume in both groups (P = 0.006). Controls showed a positive correlation between total grey matter volume and income (R = 0.14, P = 0.02). Surprisingly, this relationship was not present in patients with schizophrenia (R =-0.076, P = 0.17). Voxel-level analysis confirmed that this interaction was widespread across the cortex. After adjusting for global brain changes, income was positively related to prefrontal cortex volumes only in controls. Conversely, the hippocampus in patients with schizophrenia, but not in controls, was relatively larger in affluent environments. There was no significant correlation between environmental violence and brain structure. Conclusions Our results highlight the interplay between environment, particularly poverty, and individual characteristics in psychosis. This is particularly important for harsh environments such as low- A nd middle-income countries, where potentially less brain vulnerability (less grey matter loss) is sufficient to become unwell in adverse (poor) environments.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal College Of Psychiatrists
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GREY MATTER
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MAGNETIC RESONANCE IMAGING
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POVERTY
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SCHIZOPHRENIA
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VIOLENCE
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Psiquiatría
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Structural brain abnormalities in schizophrenia in adverse environments: Examining the effect of poverty and violence in six Latin American cities
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-04T15:33:12Z
dc.identifier.eissn
1472-1465
dc.journal.volume
218
dc.journal.number
2
dc.journal.pagination
112-118
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Crossley, Nicolas A.. Pontificia Universidad Católica de Chile; Chile
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Fil: Zugman, Andre. Universidade Federal de Sao Paulo; Brasil
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Fil: Reyes Madrigal, Francisco. Instituto Nacional de Neurología y Neurocirugía; México
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Fil: Czepielewski, Leticia S.. Universidade Federal do Rio Grande do Sul; Brasil
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Fil: Castro, Mariana Nair. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
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Fil: Diaz Zuluaga, Ana M.. Universidad de Antioquia; Colombia
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Fil: Pineda Zapata, Julian A.. No especifíca;
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Fil: Reckziegel, Ramiro. Universidade Federal do Rio Grande do Sul; Brasil
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Fil: Gadelha, Ary. Universidade Federal de Sao Paulo; Brasil
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Fil: Jackowski, Andrea. Universidade Federal de Sao Paulo; Brasil
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Fil: Noto, Cristiano. Universidade Federal de Sao Paulo; Brasil
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Fil: Alliende, Luz M.. Pontificia Universidad Católica de Chile; Chile
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Fil: Iruretagoyena, Barbara. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Ossandon, Tomas. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Ramirez Mahaluf, Juan P.. Pontificia Universidad Católica de Chile; Chile
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Fil: Castañeda, Carmen P.. Instituto Psiquiátrico Dr. José Horwitz Barak; Chile
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Fil: Gonzalez Valderrama, Alfonso. Universidad Finis Terrae; Chile
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Fil: Nachar, Ruben. Instituto Psiquiátrico Dr. José Horwitz Barak; Chile
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Fil: León Ortiz, Pablo. Instituto Nacional de Neurología y Neurocirugía; México
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Fil: Undurraga, Juan. Universidad del Desarrollo; Chile
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Fil: López Jaramillo, Carlos. Universidad de Antioquia; Colombia
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Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
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Fil: Gama, Clarissa S.. Universidade Federal do Rio Grande do Sul; Brasil
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Fil: De La Fuente Sandoval, Camilo. Instituto Nacional de Neurología y Neurocirugía; México
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Fil: Bressan, Rodrigo A.. Universidade Federal de Sao Paulo; Brasil
dc.journal.title
British Journal Of Psychiatry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1192/bjp.2020.143
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