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dc.contributor.author
Barros, Ana L. A. N.
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Hamed, Abdelaaty
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Marani, Mariela Mirta
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Moreira, Daniel C.
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Eaton, Peter
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Plácido, Alexandra
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Kato, Massuo J.
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Leite, José Roberto S. A.
dc.date.available
2022-08-10T12:22:25Z
dc.date.issued
2022-01
dc.identifier.citation
Barros, Ana L. A. N.; Hamed, Abdelaaty; Marani, Mariela Mirta; Moreira, Daniel C.; Eaton, Peter; et al.; The arsenal of bioactive molecules in the skin secretion of urodele amphibians; Frontiers Media; Frontiers in Pharmacology; 12; 1-2022; 1-7
dc.identifier.issn
1663-9812
dc.identifier.uri
http://hdl.handle.net/11336/164877
dc.description.abstract
Urodele amphibians (∼768 spp.), salamanders and newts, are a rich source of molecules with bioactive properties, especially those isolated from their skin secretions. These include pharmacological attributes, such as antimicrobial, antioxidant, vasoactive, immune system modulation, and dermal wound healing activities. Considering the high demand for new compounds to guide the discovery of new drugs to treat conventional and novel diseases, this review summarizes the characteristics of molecules identified in the skin of urodele amphibians. We describe urodele-derived peptides and alkaloids, with emphasis on their biological activities, which can be considered new scaffolds for the pharmaceutical industry. Although much more attention has been given to anurans, bioactive molecules produced by urodeles have the potential to be used for biotechnological purposes and stand as viable alternatives for the development of therapeutic agents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ALKALOIDS
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AMPHIBIANS
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BIOACTIVE MOLECULES
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PEPTIDES
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URODELA
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Conservación de la Biodiversidad
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The arsenal of bioactive molecules in the skin secretion of urodele amphibians
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-07-04T19:18:34Z
dc.journal.volume
12
dc.journal.pagination
1-7
dc.journal.pais
España
dc.description.fil
Fil: Barros, Ana L. A. N.. Universidade do Brasília; Brasil
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Fil: Hamed, Abdelaaty. Universidade de Sao Paulo; Brasil
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Fil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; Argentina
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Fil: Moreira, Daniel C.. Universidade do Brasília; Brasil
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Fil: Eaton, Peter. Universidad de Porto; Portugal
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Fil: Plácido, Alexandra. Universidad de Porto; Portugal
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Fil: Kato, Massuo J.. Universidade de Sao Paulo; Brasil
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Fil: Leite, José Roberto S. A.. Universidade do Brasília; Brasil
dc.journal.title
Frontiers in Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphar.2021.810821/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fphar.2021.810821
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