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dc.contributor.author
Nazari, Maryam
dc.contributor.author
Kashanian, Soheila
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Omidfar, Kobra
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Ghobadi, Sirous
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Goicoechea, Hector Casimiro
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Gu, Hui Wen
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Khodarahmi, Reza
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Jalalvand, Ali R.
dc.date.available
2022-08-09T18:00:50Z
dc.date.issued
2021-01
dc.identifier.citation
Nazari, Maryam; Kashanian, Soheila; Omidfar, Kobra; Ghobadi, Sirous; Goicoechea, Hector Casimiro; et al.; Two-and three-way chemometric analyses for investigation of interactions of acarbose with normal and glycated human serum albumin: developing a novel biosensing system; Elsevier Science; Microchemical Journal; 160; 1-2021; 1-12
dc.identifier.issn
0026-265X
dc.identifier.uri
http://hdl.handle.net/11336/164802
dc.description.abstract
In this project, our research group has performed an interesting work in which interactions of acarbose (ACB) with normal human serum albumin (HSA) and glycated HSA (GHSA) have been investigated by chemometrics assisted-electrochemical and spectroscopic techniques. To have a deep insight to the interactions of ACB with HSA and GHSA, different electrochemical and spectroscopic techniques were used to monitor ACB-HSA and ACB-GHSA interactions and analyzed by multivariate curve resolution alternating least squares (MCR-ALS), MCR-BANNDS and EQUISPEC as efficient chemometric algorithms. Then, molecular docking techniques were used to extract more information which helped us to better justify binding of ACB with HSA and GHSA. After obtaining qualitative and quantitative information and justification of the ACB-HSA and ACB-GHSA interactions, a novel electrochemical technique was developed for exploiting second-order advantage from differential pulse voltammetric data for determination of GHSA as a potential biomarker in diabetes in the presence of HSA. Calibration and validation of the developed system showed us that our system was successful in determination of GHSA in synthetic and real samples.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACARBOSE
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BIOSENSING
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GLYCATED HUMAN SERUM ALBUMIN
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HUMAN SERUM ALBUMIN
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Química Analítica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Two-and three-way chemometric analyses for investigation of interactions of acarbose with normal and glycated human serum albumin: developing a novel biosensing system
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-08T15:18:25Z
dc.journal.volume
160
dc.journal.pagination
1-12
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Nazari, Maryam. Razi University; Irán. Tehran University of Medical Sciences; Irán
dc.description.fil
Fil: Kashanian, Soheila. Razi University; Irán
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Fil: Omidfar, Kobra. Tehran University of Medical Sciences; Irán
dc.description.fil
Fil: Ghobadi, Sirous. Razi University; Irán
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Fil: Goicoechea, Hector Casimiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Desarrollo Analítico y Quimiometría; Argentina
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Fil: Gu, Hui Wen. Yangtze University; China
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Fil: Khodarahmi, Reza. Kermanshah University of Medical Sciences; Irán
dc.description.fil
Fil: Jalalvand, Ali R.. Kermanshah University Of Medical Sciences; Irán
dc.journal.title
Microchemical Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0026265X20333038
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.microc.2020.105675
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