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dc.contributor.author
Jalili, Cyrus
dc.contributor.author
Akbari, Vali
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Khodarahmi, Reza
dc.contributor.author
Goicoechea, Hector Casimiro
dc.contributor.author
Jalalvand, Ali R.
dc.date.available
2022-08-09T17:45:38Z
dc.date.issued
2021-07
dc.identifier.citation
Jalili, Cyrus; Akbari, Vali; Khodarahmi, Reza; Goicoechea, Hector Casimiro; Jalalvand, Ali R.; Electrochemical-spectroscopic-chemometric investigation of binding and inhibition of myeloperoxidase by bivalirudin: application to determination of myeloperoxidase as a biomarker for acute coronary syndrome; Elsevier Science; Microchemical Journal; 166; 7-2021; 1-30
dc.identifier.issn
0026-265X
dc.identifier.uri
http://hdl.handle.net/11336/164792
dc.description.abstract
In this paper, we are going to report results of one of our projects in which we have investigated binding and inhibition of myeloperoxidase (MO) by bivalirudin (BV) with the help of electrochemical and spectroscopic techniques assisted by chemometric methods. Different electrochemical and spectroscopic data were combined or individually used to justify binding and inhibition of the MO by BV. Hard and soft modeling chemometric methods were used to the analysis of experimental data to extract concentration profiles, pure instrumental signal profiles and binding constant value (Kb). Results of conventional and chemometric analyses confirmed a relatively strong binding of BV with MO which inhibited it. Concentration and pure instrumental signal profiles revealed interaction and binding of BV with MO and formation of one complex species. Inhibition of the MO by BV helped us to exploit a quantitative concept for electrochemical determination of the MO based on its binding with BV. Determination of the MO was performed by electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) and the results of the EIS were better than DPV which can be suggested for the analysis of serum samples with the aim of evaluation of patients with acute coronary syndrome.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
BIVALIRUDIN
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DETERMINATION
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INHIBITION
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MYELOPEROXIDASE
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Química Analítica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Electrochemical-spectroscopic-chemometric investigation of binding and inhibition of myeloperoxidase by bivalirudin: application to determination of myeloperoxidase as a biomarker for acute coronary syndrome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-08T15:18:19Z
dc.journal.volume
166
dc.journal.pagination
1-30
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Jalili, Cyrus. Kermanshah University Of Medical Sciences; Irán
dc.description.fil
Fil: Akbari, Vali. Kermanshah University Of Medical Sciences; Irán
dc.description.fil
Fil: Khodarahmi, Reza. Kermanshah University Of Medical Sciences; Irán
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Desarrollo Analítico y Quimiometría; Argentina
dc.description.fil
Fil: Jalalvand, Ali R.. Kermanshah University Of Medical Sciences; Irán
dc.journal.title
Microchemical Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0026265X21002964
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.microc.2021.106212
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