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dc.contributor.author
Mauro, Laura Valeria
dc.contributor.author
Dalurzo, Mercedes
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Carlini, María José
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Smith, David
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Núñez, Myriam Carmen
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Simian, Marina
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Lastiri, José
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Vasallo, Bartolomé
dc.contributor.author
Bal, Elisa Dora
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Pallotta, María Guadalupe
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Puricelli, Lydia Ines
dc.date.available
2017-05-15T15:48:00Z
dc.date.issued
2010-07
dc.identifier.citation
Mauro, Laura Valeria; Dalurzo, Mercedes; Carlini, María José; Smith, David; Núñez, Myriam Carmen; et al.; Estrogen receptor β and epidermal growth factor receptor as early-stage prognostic biomarkers of non-small cell lung cancer; Spandidos Publ Ltd; Oncology Reports; 24; 7-2010; 1331-1338
dc.identifier.issn
1021-335X
dc.identifier.uri
http://hdl.handle.net/11336/16477
dc.description.abstract
As 20% of stage I NSCLC patients develop recurrent and often incurable cancer, the identification of prognostic markers has a meaningful clinical application. The biological significance of steroid hormone and EGF receptors, able to regulate key physiological functions, remains elusive in NSCLC. Our aim was to investigate the prognostic input of estrogen receptors (ER·, ERß), progesterone receptors (PR) and EGFR in tumors from 58 stage I NSCLC patients. Antigen expression was analyzed by immunohistochemistry. Prognostic evaluation was performed with the multivariate Cox model. We found that about 70 and 40% of samples expressed ER· or ERß at cytoplasmic or nuclear level, respectively. Besides, only 12.1% of samples weakly expressed nuclear PR and 62.7% showed membrane EGFR staining. Correlation studies indicated an inverse association between EGFR expression and smoking status (p<0.01). Multivariate studies showed that the lack of nuclear ERß or the loss of EGFR expression were independent prognosis markers associated with shorter overall survival. We also found that patients whose tumors were negative for these two biomarkers presented the worst outcome. In conclusion, our findings could be useful for selecting stage I NSCLC patients with poor prognosis to apply an earlier treatment that impacts on survival.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Spandidos Publ Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Estrogen Receptor
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Progesterone Receptor
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Epidermal Factor Receptor
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Non Small Cell Lung Cancer
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Prognostic Biomarker
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Estrogen receptor β and epidermal growth factor receptor as early-stage prognostic biomarkers of non-small cell lung cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-10T19:57:43Z
dc.journal.volume
24
dc.journal.pagination
1331-1338
dc.journal.pais
Grecia
dc.journal.ciudad
Atenas
dc.description.fil
Fil: Mauro, Laura Valeria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Dalurzo, Mercedes. Hospital Italiano; Argentina
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Fil: Carlini, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Smith, David. Hospital Italiano; Argentina
dc.description.fil
Fil: Núñez, Myriam Carmen. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Simian, Marina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Lastiri, José. Hospital Italiano; Argentina
dc.description.fil
Fil: Vasallo, Bartolomé. Hospital Italiano; Argentina
dc.description.fil
Fil: Bal, Elisa Dora. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Pallotta, María Guadalupe. Hospital Italiano; Argentina
dc.description.fil
Fil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.journal.title
Oncology Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3892/or_00000990
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/or/24/5/1331
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