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dc.contributor.author
Narata, Ana Paula
dc.contributor.author
Obradó, Laura
dc.contributor.author
Moyano, Raquel Kalé
dc.contributor.author
Macho, Juan M.
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Blasco, Jordi
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Rueda, Antonio López
dc.contributor.author
Roman, Luis San
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Remollo, Sebastian
dc.contributor.author
Marinelli, Claudia Beatriz
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dc.contributor.author
Cepeda, Rosana
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dc.contributor.author
Fernández, Héctor
dc.contributor.author
Larrabide, Ignacio
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dc.date.available
2022-08-08T13:51:45Z
dc.date.issued
2021-09
dc.identifier.citation
Narata, Ana Paula; Obradó, Laura; Moyano, Raquel Kalé; Macho, Juan M.; Blasco, Jordi; et al.; Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data; Frontiers Media; Frontiers in Medical Technology; 3; 9-2021; 1-11
dc.identifier.uri
http://hdl.handle.net/11336/164520
dc.description.abstract
Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in theocclusion of cerebral aneurysms after treatment.Objective: Verification and Validation of computational models in terms of predictivecapacity, relating FD porosity and occlusion after cerebral aneurysms treatment.Methods: Sixty-four aneurysms, with pre-treatment and follow-up images, wereconsidered. Patient demographics and aneurysm morphological information werecollected. The computational simulation provided by ANKYRAS provided FD porosity,expansion, and mesh angle. FD occlusion was assessed and recorded from follow-upimages. Multiple regression Logit and analysis of covariance (ANCOVA) models wereused to model the data with both categorical and continuous models.Results: Occlusion of the aneurysm after 12 months was affected by aneurysmmorphology but not by FD mesh morphology. A Time-To-Occlusion (TTO) of 6.92 monthson average was observed with an SE of 0.24 months in the aneurysm populationsurveyed. TTO was estimated with statistical significance from the resulting model forthe data examined and was capable of explaining 92% of the data variation.Conclusions: Porosity was found to have the most correction power when assessingTTO, proving its importance in the process of aneurysm occlusion. Still, further Verificationand Validation (V&V) of treatment simulation in more extensive, multi-center, andrandomized databases is required.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CEREBRAL ANEURYSMS
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FLOW DIVERTER
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DEVICE SIZING
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DEVICE POROSITY
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TIME-TO-OCCLUSION
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Ciencias de la Información y Bioinformática
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dc.subject.classification
Ciencias de la Computación e Información
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-04T15:08:28Z
dc.identifier.eissn
2673-3129
dc.journal.volume
3
dc.journal.pagination
1-11
dc.journal.pais
Suiza
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dc.journal.ciudad
Lausana
dc.description.fil
Fil: Narata, Ana Paula. Hôpitaux de Tours; Francia
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Fil: Obradó, Laura. Galgo Medical S. L.; España
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Fil: Moyano, Raquel Kalé. Galgo Medical S. L.; España
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Fil: Macho, Juan M.. Hospital Clinic of Barcelona; España
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Fil: Blasco, Jordi. Hospital Clinic of Barcelona; España
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Fil: Rueda, Antonio López. Hospital Clinic of Barcelona; España
dc.description.fil
Fil: Roman, Luis San. Hospital Clinic of Barcelona; España
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Fil: Remollo, Sebastian. Hospital Universitari Germans Trias i Pujol; España
dc.description.fil
Fil: Marinelli, Claudia Beatriz. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina
dc.description.fil
Fil: Cepeda, Rosana. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina
dc.description.fil
Fil: Fernández, Héctor. Galgo Medical S. L.; España
dc.description.fil
Fil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; Argentina. Galgo Medical S. L.; España
dc.journal.title
Frontiers in Medical Technology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmedt.2021.705003/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fmedt.2021.705003
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