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dc.contributor.author
Ma, Feng
dc.contributor.author
Darabi, Maryam
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Lhomme, Marie
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Tubeuf, Emilie
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Canicio, Aurélie
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Brerault, Jean
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Medadje, Narcisse
dc.contributor.author
Rached, Fabiana
dc.contributor.author
Lebreton, Sandrine
dc.contributor.author
Frisdal, Eric
dc.contributor.author
Brites, Fernando Daniel
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dc.contributor.author
Serrano, Carlos
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Santos, Raul
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Gautier, Emmanuel
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Huby, Thierry
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El Khoury, Petra
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Carrié, Alain
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Abifadel, Marianne
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Bruckert, Eric
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Guerin, Maryse
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Couvert, Philippe
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Giral, Philippe
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Lesnik, Philippe
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Le Goff, Wilfried
dc.contributor.author
Guillas, Isabelle
dc.contributor.author
Kontush, Anatol
dc.date.available
2022-08-08T12:33:57Z
dc.date.issued
2021-05
dc.identifier.citation
Ma, Feng; Darabi, Maryam; Lhomme, Marie; Tubeuf, Emilie; Canicio, Aurélie; et al.; Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular risk; Elsevier Ireland; Atherosclerosis; 324; 5-2021; 1-8
dc.identifier.issn
0021-9150
dc.identifier.uri
http://hdl.handle.net/11336/164510
dc.description.abstract
Background and aims: While low concentrations of high-density lipoprotein-cholesterol (HDL-C) represent a well-established cardiovascular risk factor, extremely high HDL-C is paradoxically associated with elevated cardiovascular risk, resulting in the U-shape relationship with cardiovascular disease. Free cholesterol transfer to HDL upon lipolysis of triglyceride-rich lipoproteins (TGRL) was recently reported to underlie this relationship, linking HDL-C to triglyceride metabolism and atherosclerosis. In addition to free cholesterol, other surface components of TGRL, primarily phospholipids, are transferred to HDL during lipolysis. It remains indeterminate as to whether such transfer is linked to HDL-C and cardiovascular disease. Methods and results: When TGRL was labelled with fluorescent phospholipid 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI), time- and dose-dependent transfer of DiI to HDL was observed upon incubations with lipoprotein lipase (LPL). The capacity of HDL to acquire DiI was decreased by −36% (p<0.001) in low HDL-C patients with acute myocardial infarction (n = 22) and by -95% (p<0.001) in low HDL-C subjects with Tangier disease (n = 7), unchanged in low HDL-C patients with Type 2 diabetes (n = 17) and in subjects with high HDL-C (n = 20), and elevated in subjects with extremely high HDL-C (+11%, p<0.05) relative to healthy normolipidemic controls. Across all the populations combined, HDL capacity to acquire DiI was directly correlated with HDL-C (r = 0.58, p<0.001). No relationship of HDL capacity to acquire DiI with both overall and cardiovascular mortality obtained from epidemiological studies for the mean HDL-C levels observed in the studied populations was obtained. Conclusions: These data indicate that the capacity of HDL to acquire phospholipid from TGRL upon LPL-mediated lipolysis is proportional to HDL-C and does not reflect cardiovascular risk in subjects widely differing in HDL-C levels.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HDL
dc.subject
LIPOLYSIS
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LPL
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PHOSPHOLIPID
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TRIGLYCERIDE-RICH LIPOPROTEIN
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular risk
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-02T17:18:57Z
dc.journal.volume
324
dc.journal.pagination
1-8
dc.journal.pais
Irlanda
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dc.description.fil
Fil: Ma, Feng. Inserm; Francia. Université Pierre et Marie Curie; Francia
dc.description.fil
Fil: Darabi, Maryam. Inserm; Francia. Université Pierre et Marie Curie; Francia
dc.description.fil
Fil: Lhomme, Marie. Ican Institute For Cardiometabolism And Nutrition; Francia
dc.description.fil
Fil: Tubeuf, Emilie. Inserm; Francia. Université Pierre et Marie Curie; Francia
dc.description.fil
Fil: Canicio, Aurélie. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: Brerault, Jean. Inserm; Francia. Université Pierre et Marie Curie; Francia
dc.description.fil
Fil: Medadje, Narcisse. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: Rached, Fabiana. Université Pierre et Marie Curie; Francia. Inserm; Francia. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Lebreton, Sandrine. Université Pierre et Marie Curie; Francia
dc.description.fil
Fil: Frisdal, Eric. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
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Fil: Serrano, Carlos. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Santos, Raul. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Gautier, Emmanuel. Inserm; Francia. Université Pierre et Marie Curie; Francia
dc.description.fil
Fil: Huby, Thierry. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: El Khoury, Petra. Université Saint-joseph de Beyrouth; Líbano
dc.description.fil
Fil: Carrié, Alain. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: Abifadel, Marianne. Université Saint-joseph de Beyrouth; Líbano
dc.description.fil
Fil: Bruckert, Eric. Inserm; Francia. Université Pierre et Marie Curie; Francia
dc.description.fil
Fil: Guerin, Maryse. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: Couvert, Philippe. Inserm; Francia. Université Pierre et Marie Curie; Francia
dc.description.fil
Fil: Giral, Philippe. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: Lesnik, Philippe. Inserm; Francia. Université Pierre et Marie Curie; Francia
dc.description.fil
Fil: Le Goff, Wilfried. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: Guillas, Isabelle. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: Kontush, Anatol. Inserm; Francia. Université Pierre et Marie Curie; Francia
dc.journal.title
Atherosclerosis
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.atherosclerosis.2021.03.002
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